ISSN:
1573-6903
Keywords:
Cytochrome c oxidase (CO)
;
motor neuron degeneration (Mnd) mouse
;
spinal cord
;
superoxide dismutase (SOD)
;
transglutaminase (TG)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Oxidative stress is suggested as a significant causative factor forpathogenesis of neuronal degeneration on spinal cord of human ALS. Wemeasured some enzymic activities implicating neuronal degenerationprocess, such as cytochrome c oxidase (CO), superoxidedismutase (SOD), and transglutaminase (TG) in spinalcord of an animal model of ALS, motor neuron degeneration(Mnd) mouse, a mutant that exhibits progressivedegeneration of lower spinal neurons during developmental growth, andcompared them with age-matched control C57BL/6 mice. CO activity inMnd spinal cord decreased during early postnatal period, whileSOD activity reduced in later stage. In Mnd tissue, TG activityin lumbar cord was increasing during early stage, but tended to declinein later period gradually. These biochemical alterations became evidentprior to the appearance of clinical motor dysfunction which wereobserved in later stages of development in Mnd spinal cord.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1022442904179
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