ZIB

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Sortierung

Digitale Medien

Absolute bioavailability of nicotine applied to different nasal regions (1991)

Johansson, C.-J. ; Olsson, P. ; Bende, M. ; [weitere]

Springer

European journal of clinical pharmacology 41 (1991), S. 585-588

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-1041

Schlagwort(e): Nicotine ; bioavailability ; nasal spray

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The absolute bioavailability of nicotine administered nasally, as drops to the nasal conchae and nasal septum, and as a nasal spray, has been studied in eight healthy volunteers. Single nasal doses of 1 mg nicotine were given and plasma concentrations of nicotine were followed for 6 h. Compared to an intravenous infusion of nicotine, the bioavailability of the nasal administrations was 60 to 75%. The rate of absorption was fast, the maximum concentration being reached after about 10 min. In the present study, there was no significant difference in the rate or extent of absorption between the different nasal treatments.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00314989

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 1 | 1 Treffer