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Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases (1995)

Ikeda, M. ; Sato, I. ; Yuasa, T. ; [et al.]

Springer

Journal of neural transmission 100 (1995), S. 263-267

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ISSN: 1435-1463

Keywords: Amyotrophic lateral sclerosis ; cerebrospinal fluid ; cyclic GMP ; nitric oxide ; Parkinson's disease ; spinocerebellar ataxia

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary To investigate whether nitric oxide (NO) plays a role in degenerative neurologic disease (DND), we measured nitrite, nitrate and cyclic GMP in cerebrospinal fluid (CSF) samples from patients with Parkinson's disease (PD), spinocerebellar ataxia (SCA) and amyotrophic lateral sclerosis (ALS). We found no significant change in CSF nitrite, nitrate or cyclic GMP in patients with any DND compared with control values. These results suggest that NO production is preserved in PD, SCA and ALS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01276464

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