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  • 1
    Electronic Resource
    Electronic Resource
    Althesin interaction with human plasma steroid binding globulins (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 181-185 
    Details
    ISSN: 1432-1041
    Keywords: althesin ; steroid binding globulins ; drug interaction ; steroid anaesthetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were measured in human serum. In 8 male patients, the effect of i.v. administration of Althesin (a mixture of Alfx and Alfd) on the transport of testosterone (T) and cortisol (F) was studied. Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (106M−1). A significant change in the percentage of unbound T was observed during Althesin infusion, with no change in total T concentration or in the TeBG binding parameters. The results suggest that by interaction with TeBG binding sites Alfx and/or Alfd displaced T bound to TeBG, and transiently increased the percentage of unbound T. A significant increase in the concentration of F was observed during althesin infusion, while the percentage of unbound F and the CBG binding parameters were unchanged. The dose of Alfx and Alfd used was not sufficient to alter the transport of F during brief althesin anaesthesia in men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547419
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Strongly nonlinear modal equations for nearly integrable PDEs (1993)
    Springer
    Journal of nonlinear science 3 (1993), S. 393-426 
    Details
    ISSN: 1432-1467
    Keywords: nearly integrable PDE ; nonlinear modes ; modulation equations ; numerical simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary The purpose of this paper is the derivation of reduced, finite-dimensional dynamical systems that govern the near-integrable modulations ofN-phase, spatially periodic, integrable wavetrains. The small parameter in this perturbation theory is the size of the nonintegrable perturbation in the equation, rather than the amplitude of the solution, which is arbitrary. Therefore, these reduced equations locally approximate strongly nonlinear behavior of the nearly integrable PDE. The derivation we present relies heavily on the integrability of the underlying PDE and applies, in general, to anyN-phase periodic wavetrain. For specific applications, however, a numerical pretest is applied to fix the truncation orderN. We present one example of the reduction philosophy with the damped, driven sine-Gordon system and summarize our present progress toward application of the modulation equations to this numerical study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429871
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    Paper (German National Licenses)
    Fulltext
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