ISSN:
1573-9171
Keywords:
pregnane derivatives
;
hydroxylation
;
oxidation
;
rhodococci
;
16α,17α-acetonides of pregnanes
;
(R, S-variants)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A preparative method was proposed for the preparation of pregn-4-ene-9α,16α,17α-triol-3,20-dione 16α,17α-acetonide (2) from 5α-H-pregn-16-en-3β-ol-20-one (1). The key stage in the proposed sequence of the reactions is the microbiological 9α-hydroxylation and introduction of the 4-en-3-one grouping into the molecule of1 by R- and S-dissociative forms of the Rhodococcus sp. strain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00864351
Permalink