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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells (1998)
    Springer
    Pflügers Archiv 436 (1998), S. 887-893 
    Details
    ISSN: 1432-2013
    Keywords: Key words Dynorphins ; Kappa opioid receptor ; Nicotinic receptors ; Opioids ; Patch clamp ; PC12 cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The authors studied effects of opioid receptor agonists on neuronal nicotinic-receptor-mediated current in PC12 cells using whole-cell current recording. At 1 µM, [d-Ala, N-Me, Phe, Gly-ol]- enkephalin (DAMGO), a selective µ receptor agonist, or 10 µM methionine-enkephalin, a µ and δ receptor agonist, did not inhibit the current elicited by 30 µM nicotine significantly. Dynorphin A (1–17) (0.1–1 µM), an endogenous κ receptor agonist, and U50488 (0.1–10 µM), a non-peptide selective κ receptor agonist, depressed the nicotine-induced current reversibly in a dose-dependent manner. They accelerated the current decay, resulting in greater effects on the non-desensitized current than the peak current. These effects were not affected by nor-binaltrophimine, a selective κ receptor antagonist, or by inclusion of guanosine 5′-O-(2-thiobiphosphate) (GDP[β-S]), a GTP binding protein blocker, into the pipette solution. These results demonstrate that two κ opioid receptor agonists, dynorphin A (1–17) and U50488, inhibit neuronal nicotinic-receptor-mediated current without the involvement of opioid receptors or GTP binding proteins. The acceleration of the current decay suggests a direct action on nicotinic receptors such as open channel block, or augmentation of desensitization. Modulation of neuronal nicotinic receptors by dynorphins may play a role in some areas where dynorphin release sites and neuronal nicotinic receptors are colocalized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050719
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  • 2
    Electronic Resource
    Electronic Resource
    Sorption, diffusion, and partial molar volumes of C4 hydrocarbons in rubbery polymers (1995)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 33 (1995), S. 1663-1671 
    Details
    ISSN: 0887-6266
    Keywords: sorption ; diffusion ; partial molar volume ; butanes ; butenes ; butylene ; butadiene ; 1,2-polybutadiene ; poly(ethylene-co-vinyl acetate) ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Sorption and dilation isotherms and diffusion coefficients for seven hydrocarbons (n-butane, isobutane, 1-butene, cis-2-butene, trans-2-butene, isobutylene, and 1,3-butadiene) in two rubbery polymers, 1,2-polybutadiene (PB) and poly(ethylene-co-vinyl acetate) (EVAc), were measured at 25°C. Dissolution parameters (Henry's law coefficient and Flory-Huggins interaction parameter), partial molar volumes, and diffusion coefficients were determined. PB exhibited greater affinity and lower diffusivity than EVAc to the C4 gases, although the gases showed nearly the same partial molar volumes in the two polymers. The diffusivity of such elongated molecules as trans-2-butene in both polymers was higher than that of bulky molecules with similar partial molar volume, such as cis-2-butene and isobutylene. Pressure-dependent permeabilities of PB and EVAc films to the hydrocarbons were predicted and discussed based on the dissolution parameters and the diffusivities. © 1995 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1995.090331112
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  • 3
    Electronic Resource
    Electronic Resource
    Thermodynamic interactions in rubbery polymer/gas systems (1997)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 35 (1997), S. 1049-1053 
    Details
    ISSN: 0887-6266
    Keywords: thermodynamic interaction ; Flory-Huggins parameter ; rubbery polymer ; gas ; Henry's law coefficient ; partial molar volume ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Flory-Huggins interaction parameters χ for 23 gases (He, Ne, Ar, Kr, Xe, H2, N2, O2, N2O, CO2, CH4, C2H4, C2H6, C3H6, C3H8, 1,3-C4H6, four C4H8's, n-C4H10, iso-C4H10, and n-C5H12) in five rubbery polymers (1,2-polybutadiene (PB), poly(ethylene-co-vinyl acetate)) (EVAc), polyethylene (PE), polypropylene (PP), and poly(dimethyl siloxane) (PDMS) were determined from either literature data on Henry's law coefficient and partial molar volume or those on sorptive dilation for each polymer/gas system. Values of χ for the gases increased in the order of PDMS 〈 PP ≡ PB 〈 EVAc ≡ PE. Among the gases except He and H2 whose χ values are not reliable, Ne and Xe have respectively the highest and the lowest values of χ for the polyolefins. The χ values of the hydrocarbons were compared together with previously reported χ values of n-alkanes C3-C10. The dependencies of χ upon concentration and temperature were discussed on the basis of the literature data. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 1049-1053, 1997
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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