ISSN:
1573-2568
Keywords:
peptidoglycan-polysaccharide
;
contact system
;
inflammatory bowel disease
;
kininogen
;
experimental colitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A specific plasma kallikrein inhibitor, Bz-Pro-Phe-boroArg (P8720), was used to define the relationship between the kallikrein-kinin (K-K) system and acute intestinal inflammation induced by bacterial peptidoglycan-polysaccharide (PG-APS) in Lewis rats. Group I received human serum albumin (HSA) intramurally in the intestine and was treated with HSA. Group II received PG-APS and was treated with P8720. Group III received PG-APS and was treated with HSA. P8720 attenuated the decrease of high-molecular-weight kininogen and factor XI activity (group II vs group III,P〈0.01). P8720 therapy significantly but modestly decreased acute intestinal inflammation measured by gross gut score (P〈0.01) and more dramatically reduced the tissue myeloperoxidase activity (P〈0.05), a measure of granulocyte recruitment, in group II compared with group III. We conclude that the K-K system is directly involved in the pathogenesis of the acute phase of experimental acute inflammation. A specific inhibitor may modulate inflammatory bowel disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02091530
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