ISSN:
1432-1041
Schlagwort(e):
chloramphenicol
;
liver disease
;
pharmacokinetics
;
intravenous administration
;
serum albumin
;
prothrombin time index
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under the time — concentration curve (AUC) showed an increase. The t1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00542103
Permalink