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  • pharmacokinetics  (3)
  • genetic variation  (2)
  • mouse genetics  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Studies on genetic variation in major urinary protein synthesis in mouse liver (1983)
    Springer
    Biochemical genetics 21 (1983), S. 15-23 
    Details
    ISSN: 1573-4927
    Schlagwort(e): major urinary proteins ; genetic variation ; mouse genetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract A two- to fourfold difference in the relative rate of total major urinary protein (MUP) synthesis between C57BL/6J and C3H/HeJ female mice has been analyzed at the genetic and molecular levels. The C57BL/6J phenotype is dominant in F1 female progeny of a cross between the two strains. Quantitation of MUP mRNA levels indicates that the rate of synthesis variation does not reflect a change in the concentration of total MUP mRNA. In recombinant inbred strains derived from C57BL/6J and C3H/HeJ progenitors, the rate of synthesis difference segregates as a single genetic determinant that is not linked to the Mup-a locus on chromosome 4. The results suggest an unlinked locus that acts to alter total MUP synthesis without altering total MUP mRNA levels. Two models are proposed to describe the action of this locus, both of which imply some sort of posttranscriptional control of MUP synthesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00000002
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Studies on genetic variation in major urinary protein synthesis in mouse liver (1983)
    Springer
    Biochemical genetics 21 (1983), S. 15-23 
    Details
    ISSN: 1573-4927
    Schlagwort(e): major urinary proteins ; genetic variation ; mouse genetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract A two- to fourfold difference in the relative rate of total major urinary protein (MUP) synthesis between C57BL/6J and C3H/HeJ female mice has been analyzed at the genetic and molecular levels. The C57BL/6J phenotype is dominant in F1 female progeny of a cross between the two strains. Quantitation of MUP mRNA levels indicates that the rate of synthesis variation does not reflect a change in the concentration of total MUP mRNA. In recombinant inbred strains derived from C57BL/6J and C3H/HeJ progenitors, the rate of synthesis difference segregates as a single genetic determinant that is not linked to theMup-a locus on chromosome 4. The results suggest an unlinked locus that acts to alter total MUP synthesis without altering total MUP mRNA levels. Two models are proposed to describe the action of this locus, both of which imply some sort of posttranscriptional control of MUP synthesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395388
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    Physiological pharmacokinetic parameters for cis-dichlorodiammineplatinum(II) (DDP) in the mouse (1992)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 20 (1992), S. 95-99 
    Details
    ISSN: 1573-8744
    Schlagwort(e): pharmacokinetics ; physiological model ; cisplatin ; DDP ; cis-dichlorodiammineplatinum(II)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01143187
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Physiological pharmacokinetic modeling ofcis-dichlorodiammineplatinum(II) (DDP) in several species (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 131-155 
    Details
    ISSN: 1573-8744
    Schlagwort(e): pharmacokinetics ; physiological model ; cisplatin ; DDP ; cis-dichlorodiammineplatinum(II)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A physiological pharmacokinetic analysis ofcis-dichlorodiammineplatinum(II) (DDP) is presented for the rabbit, dog, and human. The results are compared to a previous analysis for the rat. DDP binds irreversibly to low-molecular weight nucleophiles and macromolecules to form mobile and fixed metabolites at rates which are tissue-specific. The rate constant for the formation of fixed metabolite in plasma, determined by in vitro incubation, ranges from 0.004 to 0.008 min−1.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01065258
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Physiologic model for the pharmacokinetics of 2′deoxycoformycin in normal and leukemic mice (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 519-534 
    Details
    ISSN: 1573-8744
    Schlagwort(e): pharmacokinetics ; physiologic model ; 2′deoxycoformycin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A flow-limited physiologic mathematical model has been developed to describe the time course of 2′deoxycoformycin (2′dCF) concentrations in the plasma and tissues of mice following iv and ip doses. Urinary excretion is modeled as a linear process involving filtration and secretion, since kidney clearance exceeded estimated glomerular filtration rate. Intracellular binding is described as the sum of linear nonspecific binding plus strong saturable binding to adenosine deaminase. Pharmacokinetic parameters are determined by a sequential optimization scheme in which each tissue is studied by means of a hybrid model. The model has been used to predict pharmacokinetic behaviour of 2′dCF in both normal and leukemic mice, and model simulations are compared with published data.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01061024
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