ISSN:
1573-8744
Keywords:
pharmacokinetics
;
physiological model
;
cisplatin
;
DDP
;
cis-dichlorodiammineplatinum(II)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A physiological pharmacokinetic analysis ofcis-dichlorodiammineplatinum(II) (DDP) is presented for the rabbit, dog, and human. The results are compared to a previous analysis for the rat. DDP binds irreversibly to low-molecular weight nucleophiles and macromolecules to form mobile and fixed metabolites at rates which are tissue-specific. The rate constant for the formation of fixed metabolite in plasma, determined by in vitro incubation, ranges from 0.004 to 0.008 min−1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01065258
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