ISSN:
1432-1041
Keywords:
Beta-adrenoceptor blockade
;
cardioselectivity
;
practolol
;
plasma levels
;
cardiac and pulmonary effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In a group of 6 healthy (but physically unfit) volunteers an investigation was made of whether there was a true plasma level effect relationship and absolute “cardioselectivity” with respect to beta-adrenoceptor blockade due to practolol. To this end three treatments were given orally, namely placebo, practolol 100 mg and practolol 400 mg. Cardiac beta-adrenoceptor blockade was assessed by measuring the inhibition of exercise heart rate and pulmonary beta-adrenoceptor blockade was assessed by measuring the reduction in exercise peak flow rate, up to 24 h after each dose. Plasma practolol levels were determined spectrophotometrically. From the results obtained there was no reason to doubt the existence of a valid relationship between cardiac beta-adrenoceptor blocking activity and the plasma concentration of practolol. It was also concluded that even in non-asthmatics, practolol does not possess absolute “cardioselectivity” since significant reductions in peak flow rate were discernible during vigorous exercise, particularly when the large dose had been given.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561399
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