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  • 1
    Electronic Resource
    Electronic Resource
    Human platelets contain a novel 47 kDa thiol-oxidase having affinity for genomic sterol-regulatory sequence (1998)
    Springer
    Molecular and cellular biochemistry 178 (1998), S. 383-385 
    Details
    ISSN: 1573-4919
    Keywords: SRE sequence affinity ; 47 kDa factor ; thiol-oxidase activity ; platelets ; lymphocytes ; CML patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The present study provides evidence to support that human platelets possess a 47 kDa dual functional molecule having thiol-oxidase activity as well as high affinity for the SRE sequence in the human genome. On the basis of these as well as earlier results, we propose that Receptor 'Ck' dependent regulation of this dual functional 47 kDa molecule may provide a mechanism for the maintenance of cellular cholesterol homeostasis. Further, this mechanism nay also explain the molecular basis of cholesterol-feedback lesion observed under premalignant conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006853001631
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence and nature of a novel thiol-oxidase in human platelets (1996)
    Springer
    Molecular and cellular biochemistry 159 (1996), S. 81-84 
    Details
    ISSN: 1573-4919
    Keywords: cholesterol ; Receptor-‘C’k ; thiol-oxidase ; platelets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The study, addressed to understand whether or not human platelets possess a unique thiol-oxidase whose activity could be modulated by signalling pathway initiated upon the activation of Receptor-‘C’k revealed the existence of disulphide-dependent oxidation within these cells and this phenomenon was regulated by Receptor-‘C’k-dependent generation of second messengers especially phosphatidic acid (PA); cAMP and cGMP. Purification of this activity revealed the existence of 47 kDa protein having thiol-oxidase activity. Keeping in view these results we propose that the existence of this novel 47 kDa Thiol-oxidase within human platelets may provide a ‘crucial switch’ for the regulation of Receptor-‘C’k-dependent mevalonate pathway in human platelets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226066
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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