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Digitale Medien

Effect of hyperkalemia on insulin secretion (1991)

Martinez, R. ; Rietberg, B. ; Skyler, J. ; [weitere]

Springer

Cellular and molecular life sciences 47 (1991), S. 270-272

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Details

ISSN: 1420-9071

Schlagwort(e): Insulin ; potassium ; hyperkalemia ; portal vein ; glucose

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68±0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p〈0.05). We conclude that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01958157

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