ISSN:
1573-9171
Keywords:
pentarane
;
progestin
;
Clauberg-McPhail assay
;
antihormonal action
;
progesterone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Some derivatives of progestins of the pregna-D6′-pentarane series have been obtained and examined for their possible hormonal and antihormonal activity in the Clauberg-McPhail assay as well as in the pregnancy maintenance test in ovariectomized rabbits. 16α, 17α-Cyclohexanoprogesterones of the 19-methyl and 19-nor series (1–4) saturated in ring A, which are inactive as progestins, exhibited a remarkable antiprogesterone effect. They decreased the McPhail index under combined administration with progesterone in a dose-dependable manner and completely inhibited the action of the latter in the pregnancy maintenance test.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00702407
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