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Digitale Medien

Effect of experimental diabetes and glucagon on cAMP-dependent protein kinase in rat liver (1977)

Weber, H. E. ; Menahan, L. A. ; Chaudhuri, S. N. ; [weitere]

Springer

Diabetologia 13 (1977), S. 153-157

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Details

ISSN: 1432-0428

Schlagwort(e): Liver ; protein kinase ; cyclic AMP ; alloxan diabetes ; insulin ; glucagon

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+ cAMP) and an increase in the activity ratio $$\frac{{( - cAMP)}}{{( + cAMP)}}$$ in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in liver. Glucagon administered in vivo to normal rats caused an increase in the activity ratio and a decrease in total protein kinase activity in liver. The changes are similar to those in diabetes. A decrease in the ratio of insulin to glucagon in diabetes may account for the changes in protein kinase observed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00745144

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