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Digitale Medien

The role of the kidney in the elimination of cephapirin in man (1975)

Cabana, B. E. ; Harken, D. R. ; Hottendorf, G. H. ; [weitere]

Springer

Journal of pharmacokinetics and pharmacodynamics 3 (1975), S. 419-438

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Details

ISSN: 1573-8744

Schlagwort(e): cephapirin ; desacetylcephapirin ; cephalosporin ; renal clearance calculations ; renal metabolism

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract A pharmacokinetic model was developed to describe the absorption, distribution, metabolism, and excretion of cephapirin and its major metabolite, desacetylcephapirin, following intravenous and intramuscular administration of cephapirin in healthy adult subjects. The model involved a two-compartment open model for cephapirin in plasma and extravascular tissues and included metabolism of cephapirin to desacetylcephapirin in both the plasma compartment and the kidney. Renal metabolism of cephapirin was followed by excretion of the desacetylcephapirin into the urine. Clearance calculations and digital computer simulation supported these features of the model.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01059474

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