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  • 1995-1999  (2)
  • coupled conduction and radiation  (1)
  • reverse transcriptase  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Sequence Analysis of the Polymerase Domain of HIV-1 Reverse Transcriptase in Naive and Zidovudine-Treated Individuals Reveals a Higher Polymorphism in α-Helices as Compared with β-Strands (1999)
    Springer
    Virus genes 18 (1999), S. 203-210 
    Details
    ISSN: 1572-994X
    Schlagwort(e): reverse transcriptase ; polymerase ; zidovudine ; α-helix ; β-strand ; polymorphism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report a statistical analysis of genetic heterogeneity of the reverse transcriptase (RT)-coding region of human immunodeficiency virus type 1. Both newly determined sequences and sequences contained in the data banks have been examined. For the calculations, the viral samples and the regions within the RT molecule were divided in two groups. The viral samples were split into those from patients not subjected to antiretroviral therapy and those from patients treated with zidovudine (AZT, 3′-azido-3′-deoxythymidine) alone or in combination with other RT inhibitors. The RT-coding region was divided into segments encoding β-strands and segments encoding α-helices. A significantly lower heterogeneity was observed in β-strands relative to the α-helix coding segments. Application of the D test of Tajima has provided evidence of operation of negative (or purifying) selection in sequences from viruses of patients not subjected to antiretroviral treatment as well as in treated patients. In the group of untreated individuals, regions encoding β-strands are subjected to stronger negative selection than those encoding α-helices. It is likely that the observed differences reflect stronger functional constraints in β-strands than in α-helices of RT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008012101219
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  • 2
    Digitale Medien
    Digitale Medien
    Laser-Flash Diffusivity Measurement of Diamond Films (1998)
    Springer
    International journal of thermophysics 19 (1998), S. 951-959 
    Details
    ISSN: 1572-9567
    Schlagwort(e): coupled conduction and radiation ; diamond films ; diffusivity ; laser-flash stimulation ; semifitransparent films ; transient technique
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract A laser-flash technique with fast infrared detection for the measurement of the normal diffusivity of samples, with a thickness in the range 200 to 700 μm, is presented. The experimental apparatus for such a measurement is described. Some points specific to the diffusivity measurement of semi-transparent and highly conductive materials such as diamond are discussed. Particularly, difficulties in connection with the good conductivity and low thickness of the samples we consider are pointed out. Finally, experimental results performed within the framework of the Diamond Round Robin 2 tests for both nondiamond and diamond films are presented and the influence of the coupled conductive–radiative heat transfer is shown.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1022663611392
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