ISSN:
1573-8744
Keywords:
isoniazid
;
salivary drug levels
;
acetylation phenotyping
;
protein binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Isoniazid was administered orally to two slow acetylator subjects, and plasma and saliva samples were assayed for intact drug. Saliva/plasma concentration ratios tended to be scattered about the value of 1. The results indicate that salivary level measurements may provide a useful approach for acetylation phenotyping. However, because of instability of isoniazid in frozen specimens, analyses of drug levels had to be initiated within 1 hr from the time of collection. Protein binding studies indicated that INH is not bound to plasma proteins to any appreciable extent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059476
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