ISSN:
1572-9001
Keywords:
Androgen agonist
;
hydrogen bonding
;
X-ray crystallography
;
semiempirical calculations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Crystal structure determination and semiempirical AM1 and PM3 calculations were performed on flutamide {2-methyl-N[4 nitro-3-(trifluoromethyl) phenyl] propamide}, a powerful nonsteroidal androgen antagonist. The molecule is almost planar apart from CF3, NO2, and CH3 groups. The NO2 plane makes an angle of 36.3(4)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02265349
Permalink