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  • 1
    Digitale Medien
    Digitale Medien
    Model Investigations of Controlled Release of Bioactive Compounds from Thin Metal Oxide Layers (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 651-654 
    Details
    ISSN: 1573-4846
    Schlagwort(e): silica ; composite layers ; controlled release ; penetration agents
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Thin composite layers of silica with incorporated bioactive organic compounds (BOC) can be prepared by mixing metal oxide sols with dissolved BOC and coating with a conventional film coating machine. The release of antibacterial benzoic acid from the silica layers into a surrounding aqueous medium can be controlled by the mass ratio of silica to benzoic acid, by modification of the silica matrix and by addition of soluble or swelling penetration agents, respectively. Therefore, such composite materials are applicable for controlled release sytems in medicine and biology with excellent long-time effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018376427531
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Model investigations of controlled release of bioactive compounds from thin metal oxide layers (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 651-654 
    Details
    ISSN: 1573-4846
    Schlagwort(e): silica ; composite layers ; controlled release ; penetration agents
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Thin composite layers of silica with incorporated bioactive organic compounds (BOC) can be prepared by mixing metal oxide sols with dissolved BOC and coating with a conventional film coating machine. The release of antibacterial benzoic acid from the silica layers into a surrounding aqueous medium can be controlled by the mass ratio of silica to benzoic acid, by modification of the silica matrix and by addition of soluble or swelling penetration agents, respectively. Therefore, such composite materials are applicable for controlled release sytems in medicine and biology with excellent long-time effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02436917
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Sol-Gel Carrier Systems for Controlled Drug Delivery (1998)
    Springer
    Journal of sol gel science and technology 13 (1998), S. 277-281 
    Details
    ISSN: 1573-4846
    Schlagwort(e): silica ; composites ; nifedipine ; polyethyleneglycol ; controlled release
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Embedding of the well-known coronary therapeuticum nifedipine into a modified silica matrix by the sol-gel technique allows its releasing behavior to be controlled to a high degree. The liberation rate is proportional to temperature and is increased by the addition of penetration agents such as sorbitol, but is inversely proportional to particle size and is decreased by modification of the silica matrix with methyl-triethoxysilane or polyethylene-glycol. It is presumed that the drug is dispersed in the gel matrix and that diffusion occurs through solvent-filled capillary channels. The liberation rate is governed by the relationship between the rates of dissolution and diffusion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008603622543
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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