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  • Conditional overexpression  (1)
  • single daily dose  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Clobazam: Single or divided doses? (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 235-238 
    Details
    ISSN: 1432-1041
    Keywords: clinical trial ; matched pairs ; anxiety ; clobazam ; single daily dose ; multiple daily doses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The results of treatment of neurotic disorders with single or divided daily doses of the anxiolytic drug clobazam have been compared. The trial was performed in two groups, each of 57 patients, paired according to age, sex, diagnosis, severity of initial disorder, and total daily dose. The 114 subjects formed a random subgroup from a total of 1369 patients taking part in a postmarketing surveillance trial of clobazam. In view of the changes in the overall severity of the symptoms, in “persistent anxiety” and “anxiety crises”, in “sleep disorders”, the global clinical impression and the tolerance, it is concluded that clobazam is a useful drug in the treatment of anxiety, and that single or divided daily dosage schedules produce similar results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545221
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gene isolation inArabidopsis thaliana by conditional overexpression of cDNAs toxic toSaccharomyces cerevisiae: identification of a novel early response zinc-finger gene (1996)
    Springer
    Molecular genetics and genomics 252 (1996), S. 587-596 
    Details
    ISSN: 1617-4623
    Keywords: Conditional overexpression ; RING finger ; mRNA decay ; Transmembrane domain ; Histone H1 ; Auxin response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In an effort to identify novel regulatory plant genes, conditional overexpression of toxicArabidopsis thaliana gene products inSaccharomyces cerevisiae was evaluated as a genetic selection scheme. The screening method was tested on a fraction of a cDNA expression library and led to the identification of two Arabidopsis cDNA clones that were toxic to yeast; one corresponded to histone H1 and the other to a previously unidentified gene. This new gene, namedATL2, combines a RING-like zinc-binding motif and a putative signal anchor sequence for membrane insertion in the same molecule. Furthermore, inspection of the 3′ untranslated region reveals two types of sequences which appear to be key determinants in rapid transcript decay. Indeed, rapid and transient accumulation of transcript occurs in the presence of a protein synthesis inhibitor and of the growth regulator auxin. These features provide evidence thatATL2 is an early-response gene. Thus,ATL2 represents one of the first early-response plant genes to be described which possesses a distinct regulatory domain; the fact thatATL2 mRNA is induced by auxin suggests that it might have a role during the response of plants to this growth regulator.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02172405
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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