ISSN:
1573-675X
Keywords:
Alzheimer's disease
;
apoptosis
;
hypoxia-ischaemia
;
neuronal death
;
programmed cell death
;
stroke.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The importance of caspases in developmental neuronal death is well-established. Recent data provide compelling evidence of caspase activation after ischaemic brain injury. Caspase inhibitors reduce cell death in several models of ischaemic injury. This review summarizes our current understanding of caspase function in ischaemic brain injury and examines the accumulating evidence of caspase participation in several neurodegenerative diseases. The therapeutic consequences of caspase inhibitor treatment in reducing cell death after such injury are also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009602401251
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