ISSN:
1432-2013
Keywords:
T lymphocytes
;
cationic amino acid transport
;
T cell early antigen gene
;
system y+
;
system y+L
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Lysine influx (2 μM) into activated human B and T lymphocytes through transport systems y+ and y+L was measured. In activated T cells very substantial activation of system y+ was detected; system y+L was also activated in these cells but with a slower time course and to a smaller extent. No stimulation of either system was found in activated B cells. The time course of activation of system y+ precisely matched the expression of the T cell early antigen gene described by MacLeod et al, 1990. The functional significance of these observations with respect to L-arginine transport and nitric oxide synthesis in activated T lymphocytes is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00381518
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