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    Electronic Resource
    Electronic Resource
    Effect of pH and glutathione on lipid peroxidation in tocopherol-enriched liposomes (1995)
    Springer
    Bulletin of experimental biology and medicine 120 (1995), S. 908-910 
    Details
    ISSN: 1573-8221
    Keywords: liver microsomes ; tocopherol ; glutathione
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Tocopherol-enriched liver microsomes are more resistant to lipid peroxidation at an alkaline pH of 8.5 in comparison with microsomes incubated at pH 7.5. An alkaline pH provides conditions for two-electron oxidation of tocopherol, which causes the lipid molecule to revert to the initial state (O2/H exchange). A possible mechanism of inhibition of lipid peroxidation within the physiological range of pH with participation of a glutathione-dependent enzyme is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02445013
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