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The evaluation of histamine antagonists in man (1971)

Fowle, A. S. E. ; Hughes, D. T. D. ; Knight, G. J.

Springer

European journal of clinical pharmacology 3 (1971), S. 215-220

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ISSN: 1432-1041

Keywords: Antihistaminics ; triprolidine ; histamine ; experimental design ; cyclizine

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary A new method for evaluating histamine antagonists in man is described based on diminution of the effects of intradermal histamine. The inter and intra subject variability of such effects is examined experimentally and previous descriptions reviewed. Measures are adopted to minimise the effects and so achieve maximum economy of drug administrations and subjects. The method is exemplified by comparisons of activity of different preparations of triprolidine and of cyclizine and chlorcycline.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00565009

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