ISSN:
1573-7373
Keywords:
meningioma
;
angiogenesis
;
tumor growth
;
metastasis
;
TNP-470, AGM-1470
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Meningiomas are relatively common (22%) vascular brain tumors. 3–11% of meningiomas are malignant, and defy currently available therapy. Inhibition of neovascularization is one potential strategy for treating these hypervascular tumors. Inhibition of tumor-induced angiogenesis by TNP-470 (previously termed AGM-1470), a synthetic analogue of fumagillin, was tested on the growth of human non-malignant and malignant meningiomas in nude mice. TNP-470 significantly inhibited tumor neovascularization and tumor growth of both non-malignant and malignant meningiomas. TNP-470 is now in human trial and should be tested for efficacy in treating malignant or recurrent aggressive meningiomas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01058456
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