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  • 1
    Electronic Resource
    Electronic Resource
    Impaired tyrosine-kinase activity of muscle insulin receptors from hypomagnesaemic rats (1995)
    Springer
    Diabetologia 38 (1995), S. 1262-1270 
    Details
    ISSN: 1432-0428
    Keywords: Key words Magnesium ; insulin receptors ; tyrosine kinase ; skeletal muscle ; insulin secretion ; glucose disposal ; GLUT 4.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of magnesium deficiency on glucose disposal, glucose-stimulated insulin secretion and insulin action on skeletal muscle was investigated in rats which were fed a low magnesium-containing diet for 4 days. Control rats were fed a standard diet. Compared to the control rats, the rats fed with low magnesium diet presented: 1) lower serum magnesium levels (0.45 ± 0.02 vs 0.78 ± 0.01 mmol/l, p 〈 0.001), 2) higher basal serum glucose (6.8 ± 0.2 vs 5.5 ± 0.2 mmol/l, p 〈 0.05) and similar basal serum insulin, 3) 40 % reduction (p 〈 0.001) in the glucose disappearance rate after its i. v. administration, and 4) 45 % reduction (p 〈 0.05) in the glucose-stimulated insulin secretion. The insulin action upon the glucose uptake by skeletal muscle was determined by means of hindquarter perfusions. Compared with control rats, magnesium-deficient rats presented: 1) normal basal glucose uptake, 2) lower stimulatory effect on the glucose uptake by insulin at the concentrations of 5 × 10−10 mol/l (3.0 ± 0.9 vs 5.4 ± 0.6, p 〈 0.05) and 5 × 10−9 mol/l (6.3 ± 0.5 vs 8.0 ± 0.5, p 〈 0.05), 3) normal glucose uptake at a maximal insulin concentration of 1 × 10−7 mol/l, and 4) 50 % reduction in the insulin sensitivity (ED50: 1.3 ± 0.3 vs 0.55 ± 0.1 mol/l, p 〈 0.05). In partially purified insulin receptors prepared from gastrocnemius muscle, 125I-insulin binding was similar in both groups of rats. However, the autophosphorylation of the β -subunit of the insulin receptor was significantly reduced by 50 % in magnesium-deficient rats and the tyrosine kinase activity of insulin receptors toward the exogenous substrate Poly Glu4: Tyr 1 was also reduced (p 〈 0.05) by hypomagnesaemia. The abundance of the insulin-sensitive glucose transporter protein (muscle/fat GLUT4), measured by Western blot analysis using polyclonal antisera, was similar in muscles of control and hypomagnesaemic rats. These findings indicate that hypomagnesaemia has a deleterious effect on glucose metabolism due to an impairment of both insulin secretion and action. The insulin resistance observed in skeletal muscle of magnesium-deficient rats may be attributed, at least in part, to a defective tyrosine kinase activity of insulin receptors. [Diabetologia (1995) 38: 1262–1270]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401757
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  • 2
    Electronic Resource
    Electronic Resource
    Impaired tyrosine-kinase activity of muscle insulin receptors from hypomagnesaemic rats (1995)
    Springer
    Diabetologia 38 (1995), S. 1262-1270 
    Details
    ISSN: 1432-0428
    Keywords: Magnesium ; insulin receptors ; tyrosine kinase ; skeletal muscle ; insulin secretion ; glucose disposal ; GLUT 4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of magnesium deficiency on glucose disposal, glucose-stimulated insulin secretion and insulin action on skeletal muscle was investigated in rats which were fed a low magnesium-containing diet for 4 days. Control rats were fed a standard diet. Compared to the control rats, the rats fed with low magnesium diet presented: 1) lower serum magnesium levels (0.45±0.02 vs 0.78±0.01 mmol/l, p〈0.001), 2) higher basal serum glucose (6.8±0.2 vs 5.5±0.2 mmol/l, p〈0.05) and similar basal serum insulin, 3) 40% reduction (p〈0.001) in the glucose disappearance rate after its i.v. administration, and 4) 45% reduction (p〈0.05) in the glucose-stimulated insulin secretion. The insulin action upon the glucose uptake by skeletal muscle was determined by means of hindquarter perfusions. Compared with control rats, magnesium-deficient rats presented: 1) normal basal glucose uptake, 2) lower stimulatory effect on the glucose uptake by insulin at the concentrations of 5×10−10 mol/l (3.0±0.9 vs 5.4±0.6, p〈0.05) and 5×10−9mol/l (6.3±0.5 vs 8.0±0.5, p〈0.05), 3) normal glucose uptake at a maximal insulin concentration of 1×10−7 mol/l, and 4) 50% reduction in the insulin sensitivity (ED50: 1.3±0.3 vs 0.55±0.1 mol/l, p〈0.05). In partially purified insulin receptors prepared from gastrocnemius muscle, 125I-insulin binding was similar in both groups of rats. However, the autophosphorylation of the Β-subunit of the insulin receptor was significantly reduced by 50% in magnesium-deficient rats and the tyrosine kinase activity of insulin receptors toward the exogenous substrate Poly Glu4: Tyr 1 was also reduced (p〈0.05) by hypomagnesaemia. The abundance of the insulin-sensitive glucose transporter protein (muscle/fat GLUT4), measured by Western blot analysis using polyclonal antisera, was similar in muscles of control and hypomagnesaemic rats. These findings indicate that hypomagnesaemia has a deleterious effect on glucose metabolism due to an impairment of both insulin secretion and action. The insulin resistance observed in skeletal muscle of magnesium-deficient rats may be attributed, at least in part, to a defective tyrosine kinase activity of insulin receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401757
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The sorption of ethyl xanthogenate on polyester fibres. I. Electrokinetic properties (1992)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 43 (1992), S. 30-33 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Das Strömungspotential und die Adsorption von Ethylxanthogenationen an Polyesterfasern wurden bei verschiedenen Temperaturen untersucht. Die Ergebnisse zeigen, daß die Aufnahme der Ethylxanthogenationen durch die Polyesterfasern im untersuchten Temperaturbereich über die Bildung starker chemischer Bindungen erfolgt. Die Ergebnisse werden auf Basis eines nucleophilen Angriffs des negative geladenen Sauerstoffatoms in der Carbonylgruppe des Polyesters auf die Thiocarbonylgruppe des Xanthogenations interpretiert.
    Notes: An experimental investigation on the streaming potential and adsorption of ethyl xanthogenate ions on polyester fibres at various temperatures has been carried out. The results reveal that the uptake of ethyl xanthogenate ions by the polyester fibres in the tested temperature interval takes place with the establishment of strong chemical bonds. The results are interpreted on the basis of nucleophilic attack of the negatively charged oxygen in the carbonyl group of the polyester on the thiocarbonyl group of the xanthogenate ion.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1992.010430107
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Darstellung, Eigenschaften und Kristallstruktur von [2-(1′-methyl-4-imidazolyl)phenyl-1-C,3′-N]acetylacetonatopalladium(II)Professor Josef Goubeau zum 85. Geburtstage am 31. März 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 535 (1986), S. 213-218 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis, Properties, and Structure of [2-(1′-methyl-4-imidazolyl)phenyl-1-C,3′-N]-palladium(II) AcetylacetonateThe reaction of Di-μ-chloro-bis[2-(1′-methyl-4-imidazolyl)phenyl-1-C,3′-N]palladium(II) with Thallium(I) acetylacetonate yields [2-(1′-methyl-4-imidazolyl)phenyl-1-C,3′-N]palladium(II) acetylacetonate. The complex crystallizes monoclinic in the space group P21/n with the lattice constants a = 1302.4(3), b = 836.0(2), c = 1341.3(3) pm, β = 93.69(3)°. Pd has a squareplanar coordination by two O atoms of acetylacetonate, the N atom of the imidazole ring, and the C atom of the phenyl group. I.r., n.m.r., and mass spectra are reported.
    Notes: Die Umsetzung von Di-μ-chloro-bis(2-(1′-methyl-4-imidazolyl)phenyl-1-C,3′-N]palladium(II) mit Thallium(I)-acetylacetonat ergibt [2-(1′-methyl-4-imidazolyl)phenyl-1-C,3′-N]palladium(II)-acetylacetonat. Der Komplex kristallisiert monoklin in der Raumgruppe P21/n mit den Gitterkonstanten a = 1302,4(3), b = 836,0(2), c = 1341,3(3) pm, β = 93,69(3)°. Im Molekül ist Pd quadratisch planar von den beiden O-Atomen des Acetylacetonat-Liganden, einem N-Atom des Imidazol-Rings und einem C-Atom der Phenylgruppe umgeben. IR-, NMR- und Massenspektrum werden diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865350424
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  • 5
    Electronic Resource
    Electronic Resource
    The sorption of ethyl xanthogenate on polyester fibres. II. Kinetics and thermodynamics (1992)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 43 (1992), S. 223-226 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Meßergebnisse zur Kinetik und Thermodynamik der Absorption von Kaliumethylxanthogenat an Polyesterfasern bei verschiedenen Temperaturen werden mitgeteilt. Es wurde gefunden, daß eine Erhöhung der Temperatur des Systems eine Zunahme der von den Fasern aufgenommenen Menge an Ethylxanthogenationen bewirkt. Adsorptionsgleichgewicht, Geschwindigkeitskonstanten, Diffusionskoeffizienten, Aktivierungsenergie und Reaktionsenthalpie wurden bestimmt. Aus den Ergebnissen kann abgeleitet werden, daß die Absorption der Ethylxanthogenationen auf der Polyesterfaser im untersuchten Temperaturbereich unter Bildung starker chemischer Bindungen erfolgt.
    Notes: Data on the kinetics and thermodynamics of absorption of potassium ethyl xanthogenate onto polyester fibres at different temperatures are presented. It is established that the increase in temperature of the system increases the uptake of ethyl xanthogenate ions by the fibres. Adsorption equilibria, specific rate constants, diffusion coefficients, activation energy and enthalpy of reaction were determined. From the results the conclusion can be derived that the adsorption of ethyl xanthogenate ions on the polyester fibre in the investigated temperature interval takes place with establishment of strong chemical bonds.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1992.010430408
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    Paper (German National Licenses)
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