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Insulin degradation. XXVIII. Immunocytochemical localization of glutathione-insulin transhydrogenase in the pancreas, kidney and liver of normal and streptozotocin-diabetic rats and of lean and obese (ob/ob) mice (1981)

Taylor, C. A. ; Varandani, P. T.

Springer

Diabetologia 21 (1981), S. 464-469

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ISSN: 1432-0428

Keywords: Immunocytochemistry ; glutathione-insulin transhydrogenase ; thioliprotein-disulphide oxidoreductase ; streptozotocin-diabetic rats ; obese (ob/ob) mice ; pancreatic acini ; islets of Langerhans ; kidney tubules ; liver

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Glutathione-insulin transhydrogenase catalyzes the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats. Localization was achieved by an antibody to glutathione-insulin transhydrogenase using a peroxidase-antiperoxidase technique. In comparison with tissues from control animals, positive immunostaining for glutathione-insulin transhydrogenase was increased in the obese mouse but reduced in the diabetic rat. Different tissues showed considerable variation in the amount of glutathioneinsulin transhydrogenase which could be detected. In the pancreatic islets there was little or no evidence for the presence of the enzyme in peripheral cells. In the kidney, immunocytochemical staining was found only in the proximal tubules. In the liver there was a generalised distribution of the enzyme, but the greatest concentration was in the periportal region. These observations parallel the biochemical data relating to glutathione-insulin transhydrogenase, indicating that different amounts of insulin degrading activity exist in different regions of tissues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00257787

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Stable and time-dissipative finite element methods for the incompressible Navier-Stokes equations in advection dominated flows (1995)

Simo, J. C. ; Armero, F. ; Taylor, C. A.

Chichester [u.a.] : Wiley-Blackwell

International Journal for Numerical Methods in Engineering 38 (1995), S. 1475-1506

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ISSN: 0029-5981

Keywords: finite elements ; incompressible Navier-Stokes ; upwinding schemes ; Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mathematics , Technology

Notes: This paper examines a new Galerkin method with scaled bubble functions which replicates the exact artificial diffusion methods in the case of 1-D scalar advection-diffusion and that leads to non-oscillatory solutions as the streamline upwinding algorithms for 2-D scalar advection-diffusion and incompressible Navier-Stokes. This method retains the satisfaction of the Babuska-Brezzi condition and, thus, leads to optimal performance in the incompressible limit. This method, when, combined with the recently proposed linear unconditionally stable algorithms of Simo and Armero (1993), yields a method for solution of the incompressible Navier-Stokes equations ideal for either diffusive or advection-dominated flows. Examples from scalar advection-diffusion and the solution of the incompressible Navier-Stokes equations are presented.

Additional Material: 24 Ill.