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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 81 (1959), S. 5125-5128 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of natural products 50 (1987), S. 287-289 
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 76 (1954), S. 6330-6335 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 12 (1923), S. 349-354 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Droperidol ; Nebenwirkungen ; Angst ; Anspannung ; Befindlichkeit ; Postoperative Übelkeit und Erbrechen ; Key words Droperidol (side-effects) ; Anxiety ; Tension ; Overall mood ; Postoperative nausea and vomiting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: Droperidol even in low doses such as 0,5 mg to 1,25 mg can increase postoperative anxiety and state of tension. The aim of this study was to determine whether these side effects occur frequently following low-dose droperidol and to see whether these are dose related. Methods: 184 female in- and outpatients ASA grade 1 and 2 undergoing gynaecological laparoscopy were recruited to this prospective, double-blind study. General anaesthesia was standardized (induction with thiopentone, fentanyl 2 µg/kg and vecuronium 0,1 mg/kg, tracheal intubation, maintainance with enflurane in N2O/O2). Patients were randomly allocated to receive saline (n=45), 0,625 mg (n=46), 1,25 mg (n=47) or 2,5 mg (n=46) droperidol i.v. 10 minutes before the end of surgery. 1, 3, 6, and 24 hours postoperatively, the patients’ anxiety, state of tension and overall mood was evaluated using two psychological questionnaires which had been tested for the perioperative period (Erlanger anxiety and tension-scale / BSKE-EWL-test). Sedation was evaluated by the staff of the recovery room. In addition, postoperative nausea and vomiting (PONV) was assessed using a 100 mm visual analogue scale and by counting the episodes of retching or vomiting. PONV was then rated over the whole observation period as none, mild, moderate or severe using a fixed scoring algorithm. Statistical analysis was performed using the ANOVA and the chi2-test. Results: The patients did not differ with regard to biometric data, duration of surgery and anaesthesia. The postoperative scores for anxiety, state of tension and overall mood were not different between the groups at any observation time (Fig. 1: anxiety and tension: P=0,5687; figure 2: overall mood: P=0,0647). Quality of sleep in the first night after surgery was the same in all groups (Table 2 and 3). Sedation was not significantly different (Table 4; P=0,0704). Furthermore, duration of stay in the recovery room did not differ (P=0,4353). On the other hand, three patients from the 2,5 mg droperidol group had to stay unexpectedly on the ward overnight, because they had been too much sedated to be discharged at home. This was not the case with any patient from the other groups. Compared to placebo, PONV over the whole 24 h observation period was significantly reduced by droperidol (Fig. 3; P=0,0338): completely free from PONV: placebo: 41,3%, 0,625 mg droperidol: 67,4%, 1,25 mg droperidol: 53,2%, 2,5 mg droperidol: 71,7%. Also the severity of PONV was reduced. Conclusion: In gynaecological laparoscopy under general anaesthesia with tracheal intubation, we recommend droperidol 0,625 mg in the prevention of PONV, as it reduces PONV as well as 2,5 mg with no severe sedation in this dosage. Psychological side effects did not occur more frequently after droperidol compared to placebo in any of the investigated dosages.
    Notes: Zusammenfassung In vorliegender Studie wurden das Ausmaß postoperativer Angst, innerer Anspannung und allgemeiner Befindlichkeitsstörungen nach intraoperativ verabreichtem Droperidol und eine mögliche Dosisabhängigkeit dieser Nebenwirkungen untersucht. Zu diesem Zweck wurden erstmals zwei evaluierte Selbstbeurteilungsfragebögen eingesetzt. 184 ASA I und II Patientinnen, die sich einer gynäkologischen Laparoskopie in standardisierter Intubationsnarkose unterzogen, wurden in diese randomisierte, doppelblinde und plazebokontrollierte Untersuchung aufgenommen. Zehn Minuten vor Narkoseende erhielten die Patientinnen i.v. Kochsalz, 0,625 mg, 1,25 mg oder 2,5 mg Droperidol. Angst und allgemeines Befinden sowie Übelkeit und Erbrechen in der postoperativen Phase (PONV) wurden 1, 3, 6 und 24 h postoperativ registriert. Die Werte für Angst und allgemeines Befinden zeigten zu keinem Untersuchungszeitpunkt Gruppenunterschiede. Die Schlafqualität in der ersten postoperativen Nacht war in allen Gruppen gleich. Verglichen mit Plazebo wurde PONV durch Droperidol in jeder Dosierung gesenkt (p=0,0338): komplett frei von PONV: Plazebo: 41,3%, Droperidol 0,625 mg: 67,4%, 1,25 mg: 53,2%, 2,5 mg: 71,7%. Bei gynäkologischen Laparoskopien in Intubationsnarkose empfehlen wir zur Prophylaxe von PONV 0,625 mg Droperidol, da es ebensogut antiemetisch wirksam ist wie 2,5 mg. Psychische Nebenwirkungen wie Angst oder andere Befindlichkeitsstörungen treten in keiner der untersuchten Droperidoldosierungen vermehrt auf.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 8 (1929), S. 1312-1312 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 6 (1935), S. 141-142 
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 6 (1935), S. 33-38 
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Biology and fertility of soils 27 (1998), S. 127-131 
    ISSN: 1432-0789
    Keywords: Key words Soil microbial biomass ; Soil enzymes ; Sugar cane ; North Queensland ; Long-term monoculture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  As part of a broader study, the aim of which is to identify soil factors that might be associated with yield decline of sugar cane, microbial biomass and protease activities were examined in soil samples collected from seven paired old and new land sites in three cane-growing districts of north Queensland. No consistent changes in soil protease activities were observed, although some sites exhibited specific effects, as a result of extensive periods of sugar cane monoculture. Soil microbial biomass, however, was significantly lower in those soils where sugar cane had been grown for extended periods. The implications of a lowering of soil microbial biomass on sugar cane yields and sustainability are discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 163 (1931), S. 223-244 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Durch geeignete Vorbehandlung von Meerschweinchen mit einer 10 proz. Paraphenylendiaminvaseline gelingt es, die Tiere gegen Paraphenylendiamin spezifisch überempfindlich zu machen. Die auf diese Weise entstandene Idiosynkrasie ist auf die Haut beschränkt; ihre Reaktionsform ist die ekzematöse. Sie bezieht sich zum mindesten schon sehr früh als Gruppenüberempfindlichkeit auch auf andere Amine, und zwar nur auf solche, welche ohne weitere Kernsubstitution Chinonkörper bilden können. Auch bei der Salvarsanüberempfindlichkeit der Meerschweinchen besteht eine derartige, gegen aromatische Arsenverbindungen vom Typus des Salvarsans gerichtete Gruppenspezifität. Die Ursolidiosynkrasie der Meerschweinchen kommt zustande, ohne daß eine Resistenzverminderung des Organismus gegen den toxischen Effekt des Paraphenylendiamins auftritt. Auch eine Gewöhnung konnte nicht festgestellt werden. Es gelingt also, Meerschweinchen durch rein percutane Einwirkung von Paraphenylendiaminbase so zu sensibilisieren, daß eine Idiosynkrasie zustande kommt; es gelingt aber nicht, eine im eigentlichen Sinne anaphylaktische Reaktivität zu erzeugen.
    Type of Medium: Electronic Resource
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