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Digitale Medien

A review of recent journal highlights focusing on atopic dermatitis (2003)

Allam, J.-P. ; Bieber, T.

Oxford, UK : Blackwell Science Ltd

Clinical and experimental dermatology 28 (2003), S. 0

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ISSN: 1365-2230

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1365-2230.2003.01361.x

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2

Digitale Medien

In search for predictive factors for atopy in human cord blood (2005)

Allam, J. P. ; Zivanovic, O. ; Berg, C. ; [weitere]

Oxford, UK : Munksgaard International Publishers

Allergy 60 (2005), S. 0

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ISSN: 1398-9995

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Since early prevention is regarded as an important corner stone in the management of atopic diseases, the identification of reliable markers detecting individuals at risk are of major interest. Therefore, many efforts have been made to unravel reliable predictors for atopy which might identify children at risk and allow the initiation of preventive strategies at an early stage. In the past, much scientific energy has been forced in particular on the development of as noninvasive methods as possible to reach this goal. It is obvious that the identification of markers for atopy at the earliest time of life – namely immediately after birth – represents one of the most attractive attempts. In consequence various studies have been initiated to address this issue investigating markers for atopy in cord blood. Most of them have been geared to our current knowledge about cellular and soluble factors which are dysregulated in adolescent atopic individuals. Although the findings of these studies will improve our knowledge about the initial evolution of atopy, several parameters evaluated did not show any association or have led to almost conflicting results. In order to provide an up-date about the current developments in this field, recent research findings on predictive factors for atopy in cord blood are summarized in the following synopsis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00815.x

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3

Digitale Medien

The role of antigen presenting cells at distinct anatomic sites: they accelerate and they slow down allergies (2004)

Novak, N. ; Allam, J.-P. ; Betten, H. ; [weitere]

Oxford, UK : Munksgaard International Publishers

Allergy 59 (2004), S. 0

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ISSN: 1398-9995

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: It has been repeatedly demonstrated that allergic reactions are driven by the continuous flow of antigen uptake and presentation processes, which are perpetuated mainly by dendritic cells (DC). The ability of allergens to cause allergic inflammation is contingent upon the presence of an immunological milieu and microenvironment that either privileges Th2 responses or prohibits these reactions by the induction of contraregulatory anti-inflammatory activities of the immune system. In the light of recent developments it appears that DC have to manage two opposing tasks: on the one hand they can favor pro-inflammatory reactions and actively induce a T-cell response, yet on the other hand they serve an important function as ‘silencers’ in the immune system by sending out anti-inflammatory, tolerance inducing signals. This unique capacity of DC has opened several exciting possibilities for a role of DC in both – accelerating and slowing down allergic reactions. It is therefore a challenge to understand in which way DC subtypes located at distinct anatomic sites with frequent allergen exposure, such as the skin, the nasal mucosa, the respiratory tree or the mucosa of the intestinal tract can have an impact on mechanisms involved in tolerance induction or effective immunity.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1398-9995.2003.00337.x

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4

Digitale Medien

New treatment modalities for granuloma faciale (2003)

Ludwig, E. ; Allam, J.-P. ; Bieber, T. ; [weitere]

Oxford, UK : Blackwell Science Ltd

British journal of dermatology 149 (2003), S. 0

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ISSN: 1365-2133

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Granuloma faciale (GF) is a rare, chronic skin disorder in which numerous treatment modalities have been used without any consistent long-term effect. We report three cases of GF, two of which were successfully treated with the Laserscope potassium-titanyl-phosphate 532-nm laser within 2 weeks and one with topical tacrolimus ointment 0·1%. Our observations suggest that these new treatment modalities for GF, which we report here for the first time, can provide effective and non-invasive treatment for this disease.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05550.x

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