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  • 1
    Digitale Medien
    Digitale Medien
    Clinical Pharmacology of Acute Allergic Disorders (1980)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 31 (1980), S. 181-190 
    Details
    ISSN: 0066-4219
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.me.31.020180.001145
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  • 2
    Digitale Medien
    Digitale Medien
    The Pharmacological Control of Immediate Hypersensitivity (1981)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 21 (1981), S. 63-81 
    Details
    ISSN: 0362-1642
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.pa.21.040181.000431
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  • 3
    Digitale Medien
    Digitale Medien
    Neuropeptides and the pathogenesis of allergy (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 42 (1987), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1987.tb02180.x
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  • 4
    Digitale Medien
    Digitale Medien
    Calcitonin gene-related peptide, endothelin-1, the cutaneous microvasculature and Raynaud's phenomenon (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: It has been argued that the digital cutaneous microvasculature is the site of the anomaly which causes Raynaud's phenomenon (RP). Both endothelin-1 (ET-1), a potent vasoconstrictor peptide present in the digital cutaneous microvasculature. and calcitonin gene-related peptide (CGRP). a powerful vasodilator present in digital cutaneous perivascular nerves, have been implicated in the pathogenesis of RP. Circulating ET-1 levels are raised, and there is a diminution of CORP-containing perivascular nerves in linger skin in RPWe undertook a pharmacological study to investigate the sensitivity of the digital cutaneous microvasculature to intradermal ET-l and CGRP. Differences were found in RP compared with normal digital skin, supporting the idea that the digital cutaneous microvasculature is actively involved in the pathogenesis of RP. In RP, the erythematous response to ET-1 was diminished at both 20 and 5°C (a low temperature at which RP classically occurs) providing pharmacological support for the morphological evidence that in RP there is a deficiency of CGRP-containing nerves in the distal digital skin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.22757.x
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  • 5
    Digitale Medien
    Digitale Medien
    Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process (1973)
    [s.l.] : Nature Publishing Group
    Nature 245 (1973), S. 249-251 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Mast cells can be induced to secrete histamine by an ionophore, the action of which depends on the presence of calcium within a specific concentration range. The fact that labelled calcium can be seen to enter sensitized cells during histamine secretion in the presence of antigen suggests that the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/245249a0
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  • 6
    Digitale Medien
    Digitale Medien
    Human basophil degranulation is not triggered by very dilute antiserum against human IgE (1993)
    [s.l.] : Nature Publishing Group
    Nature 366 (1993), S. 525-527 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] WE examined the effects of dilutions of anti-lgE from 102 to 1060 on human basophil degranulation. The original paper1 stated that anti-lgE dilutions were effective only if vigorously shaken (succussed) during preparation. We have compared the effects of succussed anti-lgE, unsuccussed anti-lgE and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/366525a0
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  • 7
    Digitale Medien
    Digitale Medien
    The effect of substance P and related peptides on the guinea-pig lung strip (1984)
    Springer
    Inflammation research 14 (1984), S. 425-428 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Substance P is present in sensory nerves in the lung and we report here its actions on the lung strip. Substance P was shown to produce rapid, small contractions of the lung strip at doses from 10−9 to 10−5 M, and there was no apparent dose-response relationship. In the presence of a mixture of three inhibitors of substance P breakdown: bacitracin, 1,4-dithio-l-threitol and ethylenediaminetetraacetic acid all at 10−4 M, the responses to substance P were greatly increased and dose-response curves could be established. The concentrations producing half maximal effect in the presence of these inhibitors were 6×10−6 M ± 4×10−6 M. The inhibitors of substance P breakdown were found to have no effect on the histamine dose-response curve: any small shifts obtained were not significant. Chlorpheniramine 10−6 M and 10−5 M shifted the histamine dose-response curve to the right producing dose ratios of 100 and 900 respectively. At these doses chlorpheniramine had no effect on the dose-response curve to substance P. A dose of substance P not itself producing a response (5×10−8 M) caused an increase in the size of the responses to histamine. The histamine dose-response curve was shifted to the left in the presence of substance P producing an average dose ratio of 1.4±0.2. In the presence of the peptidase inhibitors, dose-response curves have also been produced for physalaemin (10−7–10−5 M) and eledoisin (10−7–10−5 M).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01973843
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  • 8
    Digitale Medien
    Digitale Medien
    The substance P receptor on rat mast cells and in human skin (1984)
    Springer
    Inflammation research 14 (1984), S. 420-424 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract (D-Pro4 D-Trp7,9,10)SP4–11 (SPA) has been shown to be a competitive antagonist of the histamine releasing action of substance P in rat peritoneal mast cells. Antagonist activity of SPA is expressed in the concentration range 1 to 10 μM, but at higher concentrations SPA releases histamine. SPA inhibits the flare response induced by substance P in human skin but is without effect on the wheal response. Up to 12.5 pmol SPA produces neither wheal nor flare response by itself. The structurally related peptide, kassinin, does not cause histamine release from rat mast cells at concentrations up to 10 μM whereas the methyl ester of substance P was found to 1.6 times more active than substance P in this respect. The findings are discussed in terms of the classification of substance P receptors and the mechanism of wheal and flare in human skin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01973842
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  • 9
    Digitale Medien
    Digitale Medien
    Desensitization of rat peritoneal mast cells to substance P (1988)
    Springer
    Inflammation research 23 (1988), S. 214-216 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Rat peritoneal mast cells were pretreated for 10 min at 37°C with either substance P (SP, 3 or 6 μM) or compound 48/80 (37.5, 50 or 75 ng/ml). The effect of this pretreatment on the subsequent responsiveness of the cells to SP was studied. Both SP and compound 48/80 pretreatment of rat peritoneal mast cells inhibited the subsequent response of the cells to SP. The degree of inhibition produced by either SP or compound 48/80 was dependent on the concentration used to pretreat the cells. Inhibition of the response of the cells to SP was observed whether or not the pretreating agent was removed or remained in contact with the cells during the subsequent stimulation with SP. It is concluded that compound 48/80 and SP desensitize the cells to subsequent stimulation by SP and possible mechanisms for this are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02142544
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  • 10
    Digitale Medien
    Digitale Medien
    Some studies of the action of betahistine at H1 and H2 receptors for histamine (1986)
    Springer
    Inflammation research 18 (1986), S. 342-350 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Betahistine produced a concentration-dependent contraction of the guinea-pig ileum and was about 27 times less active than histamine in this respect. Betahistine induced desensitization of contractile responses to histamine in the guinea-pig ileum. The H1 histamine receptor antagonist mepyramine was a competitive antagonist of the action of betahistine on the guinea-pig ileum. Betahistine caused relaxation of the rat uterus contracted by acetylcholine, and this action of betahistine was blocked by the H2 receptor antagonist cimetidine. Betahistine had a concentration-dependent positive chronotropic action on isolated guinea-pig atria, and in this respect was tenfold less potent than histamine. The action of betahistine on the atria was blocked by the H2 receptor antagonist YM11170. Betahistine caused a concentration-related contraction of the isolated lung parenchymal strip of the guinea-pig, and YM11170 potentiated this effect. Betahistine failed to release histamine from rat peritoneal mast cells at concentrations up to 100 μM and it did not prevent histamine release induced by either substance P or anti-IgE. Betahistine produced a dose-related flare and wheal reaction when injected intradermally into human skin. It is concluded that betahistine has agonist activity at both H1 and H2 receptors for histamine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01964995
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