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  • 1
    ISSN: 1432-1920
    Schlagwort(e): Multiple sclerosis ; High-dose contrast-enhanced ; magnetic resonance imaging ; Gadolinium-DTPA ; Gadolinium-HP-D03A
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Contrast-enhanced MRI is effective for assessing disease activity in multiple sclerosis (MS) and may provide an outcome measure for testing the efficacy of treatment in clinical trials. To compare the sensitivity of high-dose gadolinium-HP-D03A with that of a standard dose of gadolinium-DTPA, we studied 16 patients with relapsing-remitting MS in the acute phase of the disease. Each underwent two MRI examinations within at most 48 h. The initial MRI study was with a standard dose of gadolinium-DTPA (0.1 mmol/kg), and the second one an experimental dose of gadolinium-HP-D03A (0.3 mmol/kg). No adverse effects were attributed to the contrast media. The high-dose study revealed more enhancing lesions than the standard-dose study (56 vs 38). This difference was found to be more relevant for infratentorial and small lesions. Furthermore, with the higher dose, there was a marked qualitative improvement in the visibility and delineation of the lesions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1920
    Schlagwort(e): Key words Multiple sclerosis ; High-dose contrast-enhanced magnetic resonance imaging ; Gadolinium-DTPA ; Gadolinium-HP-DO3A
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Contrast-enhanced MRI is effective for assessing disease activity in multiple sclerosis (MS) and may provide an outcome measure for testing the efficacy of treatment in clinical trials. To compare the sensitivity of high-dose gadolinium-HP-DO3A with that of a standard dose of gadolinium-DTPA, we studied 16 patients with relapsing-remitting MS in the acute phase of the disease. Each underwent two MRI examinations within at most 48 h. The initial MRI study was with a standard dose of gadolinium-DTPA (0.1 mmol/kg), and the second one an experimental dose of gadolinium-HP-DO3A (0.3 mmol/kg). No adverse effects were attributed to the contrast media. The high-dose study revealed more enhancing lesions than the standard-dose study (56 vs 38). This difference was found to be more relevant for infratentorial and small lesions. Furthermore, with the higher dose, there was a marked qualitative improvement in the visibility and delineation of the lesions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    ISSN: 1590-3478
    Schlagwort(e): mPICA infarction ; Magnetic resonance imaging ; Digital subtraction angiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Descriviamo il caso di un infarto bilaterale nel territorio delle branche mediali della arteria cerebellare postero inferiore (mPICA). La paziente, una donna di 57 anni, non aveva fattori di rischio per cerebropatia vascolare, eccettuata una lunga storia di ipertensione arteriosa. Sono state formulate diverse ipotesi patogenetiche in grado di giustificare questo inusuale sito di lesione: A) due PICA che originino da una arteria basilare occlusa; B) entrambe le branche mediali che originino dalla stessa PICA in un lato; C) una genesi emodinamica con una ipoperfusione nelle branche più periferiche delle arterie; D) un doppio simultaneo stroke embolico nel territorio delle mPICA. Sulla base del decorso clinico e degli esami strumentali (Ecodoppler dei vv. epiaortici, ecocardiogramma, RM, angioRM, TC ed angiografia digitale intrarteriosa) nessuna di queste ipotesi può essere singolarmente considerata come responsabile della lesione. Proponiamo, quindi, che una anastomosi tra le PICA debba rappresentare la necessaria predisponente condizione sulla quale siano poi intervenuti ulteriori fattori determinanti l'evento ischemico acuto.
    Notizen: Abstract We present an unusual case of simultaneous bilateral cerebellar infarction in the territory of the medial and intermediate branches of the posterior inferior cerebellar arteries (mPICA). The patient, a 57-yr old woman, had no risk factors for cerebrovascular disease but a long-standing hypertension. Pathogenetic hypotheses of this unusual ischemic site of lesion may be referred to: A) two PICAs arising from an occluded basilar artery; B) both medial branches arising from the same PICA on one side; C) a haemodynamic mechanism with hypoperfusion in the most peripheral branches of the arteries; D) a double, simultaneous embolic stroke in mPICAs territory. Based on clinical course, supraortic duplex-scan, echocardiography, MRI, angioMRI and CT scans, and digital subtraction angiography, none of these hypotheses could be clearly associated with the pathogenesis of the lesion. Nevertheless, we propose that an anomalous common mPICA for both cerebellar territories should represent the necessary condition for the ischemic insult and, simultaneously, other factors should intervene as possible determining events.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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