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  • 1
    Digitale Medien
    Digitale Medien
    Antinociceptive Properties of Pyridoxine (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 585 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb28055.x
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  • 2
    Digitale Medien
    Digitale Medien
    Suppression of Thalamic and Spinal Nociceptive Neuronal Response by Pyridoxine, Thiamine, and Cyanocobalamin (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 585 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb28085.x
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  • 3
    Digitale Medien
    Digitale Medien
    Bestimmung des zeitlichen Verlaufes der Erschlaffung der kontraktilen Elemente mit Hilfe des Spannungs-Frequenz-Diagrammes (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 676-677 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary By plotting the tension developed during maximal summation of muscle twitches against the stimulus interval, a curve can be drawn which has the same time course of the falling phase of the active state as determined by the method of quick release.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02145265
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  • 4
    Digitale Medien
    Digitale Medien
    Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord (1993)
    Springer
    Journal of molecular medicine 72 (1993), S. 65-73 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Nicotine ; Analgesia ; Nociception ; Thalamus ; Spinal cord ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To assess the possible role of nicotinergic control in nociception and pain, experiments were carried out on rats under urethane anesthesia in which nociceptive activity was elicited by electrical stimulation of afferent C fibers in the sural nerve and recorded from single neurones in the thalamus and from ascending axons in the spinal cord. Intravenous administration of nicotine (0.01–0.5 mg/kg) depressed the nociceptive activity evoked in the thalamus and the spinal cord in a dose-dependent way. The maximum depression in thalamus and spinal cord was 40% of control activity and obtained at a dose of 0.025 mg/kg. Likewise, local administration of nicotine to the spinal cord by intrathecal injection (5, 10, and 30 μg) reduced the nociceptive activity evoked in neurones of the thalamus and in ascending axons of the spinal cord, the maximum of the depression being 40% of control activity. The depressant effect of nicotine (0.05 mg/kg) was reduced by mecamylamine (1 mg/kg) but not by atropine (0.5 mg/kg). It is concluded that the antinociceptive effect of nicotine is due to a specific action of the alcaloid at the spinal level.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00231121
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  • 5
    Digitale Medien
    Digitale Medien
    Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6, B12 on nociceptive activity evoked in the rat thalamus: Dose-response relationship and combinations with morphine and paracetamol (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 129-135 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Vitamin B combination ; Vitamin B6 ; Combined administration: Morphine/Paracetamol ; Antinociception ; Evoked nociceptive activity ; Analgesia ; Thalamus ; Rat ; Acute experiment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Nociceptive activity was elicited in neurones of the thalamus by supramaximal electrical stimulation of afferent C fibres in the sural nerve of rats under urethane anesthesia. The fixed combination of vitamin B1, B6, B12 (Neurobion®) as well as of vitamin B6 administered by i.p. injection dose-dependently reduced the evoked nociceptive activity. The ED50 of Neurobion® is 4.6 ml/kg (at 100 min after injection) and that of vitamin B6 is 189mg/kg (at 90 min after injection). The minimum effective doses of Neurobion® and vitamin B6 are 0.5 ml/kg and 40 mg/kg, respectively. When Neurobion® or vitamin B6 were given at their minimum effective doses, and the minimum effective doses of morphine (0.025 mg/kg) or paracetamol (5 mg/kg) were injected i.v. 80 min later, i.e., when the maximum effect of higher doses of Neurobion® or vitamin B6was about to develop, no supraadditive effect developed. It is concluded that the antinociceptive effect caused by a single injection of Neurobion® is largely due to vitamin B6. Vitamin B12 may contribute to this effect, whereas vitamin B1 alone exhibited only a slight effect on nociception. Moreover, it appears that Neurobion® produces its antinociceptive effect after a single injection and after repeated administration during several days by different mechanisms so that the effect of analgesic agents is not enhanced following a single injection of Neurobion® but may be enhanced after repeated administration of the compound.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01646861
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  • 6
    Digitale Medien
    Digitale Medien
    Vergleichende Untersuchungen über den anaphylaktischen Schock und den Anaphylatoxinschock am intakten Meerschweinchen (1961)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 242 (1961), S. 65-75 
    Details
    ISSN: 1432-1912
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00245013
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  • 7
    Digitale Medien
    Digitale Medien
    The antagonism between reserpine and some antiparkinson drugs in electroseizure (1968)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 259 (1968), S. 442-459 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Electroseizure Threshold ; Reserpine ; Antiparkinson Drugs ; Phenytoin ; Elektrokrampfschwelle ; Reserpin ; Antiparkinsonstoffe ; Phenytoin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of amphetamine, metamphetamine, propylhexedrine, biperiden and atropine were studied in experiments on electroseizure threshold in rats. In high doses these drugs lowered the threshold of electroseizures and antagonized the threshold lowering produced by reserpine, with the exception of atropine, which enhanced the action of reserpine. Low doses of the drugs and combinations of low doses of metamphetamine, propylhexedrine and biperiden did not influence electroseizure threshold, but inhibited the action of reserpine. The effect of phenytoin on the threshold lowered by reserpine was enhanced by low doses of metamphetamine, propylhexedrine and biperiden. Tetrabenazine caused threshold lowering which was antagonized by metamphetamine, propylhexedrine, biperiden and atropine. Pretreatment with α-methyl-p-tyrosine, but not with diethyldithiocarbaminate abolished the effect of high doses of metamphetamine or propylhexedrine on the electroseizure threshold. Inhibition of the formation of DOPA or noradrenaline did not influence the action of reserpine or the antagonism between reserpine and the drugs of the amphetamine group. After a repeated injection of metamphetamine tachyphylaxis developed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00538559
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  • 8
    Digitale Medien
    Digitale Medien
    Depression by antiparkinson drugs of reserpine rigidity (1968)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 260 (1968), S. 80-88 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Rigidity ; Antiparkinson Drugs ; Metamphetamine ; Propylhexedrine ; Biperiden ; Phenytoin ; Rigor ; Antiparkinsonstoffe ; Metamphetamin ; Propylhexedrin ; Biperiden ; Phenytoin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of metamphetamine, propylhexedrine and biperiden on reserpine rigidity in the rat was assessed in an electromyographical study. For comparison the anticonvulsant agent phenytoin was also included in the investigation. Tonic electromyographical activity during stretch of the calf muscles served as an indicator of rigidity. All drugs tested and their combinations depressed the rigidity elicited by an intravenous injection of a high dose of reserpine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00545008
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  • 9
    Digitale Medien
    Digitale Medien
    The effect of physostigmine and tetrabenazine on spinal motor control and its inhibition by drugs which influence reserpine rigidity (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 263 (1969), S. 427-438 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Spinalmotorische Aktivität ; Physostigmin ; Tetrabenazin ; Monoaminergica ; Cholinolytica ; Antiparkinsonstoffe ; Phenytoin ; Spinal Motor Activity ; Physostigmine ; Tetrabenazine ; Monoaminergic Agents ; Cholinolytic Agents ; Antiparkinson Drugs ; Phenytoin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary The effect of monoaminergic (DOPA, metamphetamine, propylhexedrine) and cholinolytic agents (atropine, biperiden, caramiphen, trihexyphenidyl) on spinal motor control disturbed by physostigmine and tetrabenazine was studied in the rat. In addition the anticonvulsant agent phenytoin was included in the investigation. Physostigmine and tetrabenazine produced rigidity, increased α reflex discharge, shortened the latency of α reflex discharge and decreased γ reflex discharge. Rigidity as well as the action of physostigmine and tetrabenazine on α motor activity were inhibited by the drugs. The results are in accordance with the hypothesis that parkinsonlike rigidity in the rat results from hyperactivity of the α motor system, which is due to an imbalance between monoaminergic and cholinergic mechanisms in the brain.
    Notizen: Zusammenfassung Die Wirkung von monoaminergen (DOPA, Metamphetamin, Propylhexedrin) und cholinolytischen (Atropin, Biperiden, Caramiphen, Trihexyphenidyl) Substanzen auf die durch Physostigmin und Tetrabenazin gestörte Kontrolle der spinalen Motorik wurde an Ratten geprüft. Zusätzlich wurde das Anticonvulsivum Phenytoin in die Untersuchung einbezogen. Unter dem Einfluß von Physostigmin und Tetrabenazin entwickelte sich ein Rigor, die reflektorische Entladung von α-Motoneuronen wurde gesteigert, die Latenz der reflektorischen α-Entladung verkürzt und die Aktivität der γ-Motoneurone vermindert. Die monoaminergen und cholinolytischen Substanzen dämpften den Rigor und die gesteigerte Reflexaktivität der α-Motoneurone. Die Befunde stehen in Einklang mit der Ansicht, daß der parkinsonähnliche Rigor der Ratte auf einer Hyperaktivität des α-motorischen Systems beruht, die ihrerseits Folge des gestörten Gleichgewichtes zwischen monoaminergen und cholinergen Systemen des Gehirns ist.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00538776
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  • 10
    Digitale Medien
    Digitale Medien
    Motor disturbance induced by tremorine and oxotremorine (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 80-98 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Tremor ; Rigidity ; α andγ Motor Activity ; Tremorine ; Oxotremorine ; Antitremor Agents ; Antiparkinson Agents ; Tremor ; Rigor -α undγ-motorische Aktivität ; Tremorin ; Oxotremorin ; Antitremorstoffe ; Antiparkinsonstoffe
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The action of tremorine and oxotremorine on spinal motor activity was studied in the rat. Both tremorogenio agents increased a reflex activity and spontaneousγ activity. The increase in spontaneousγ activity consisted of rhythmic bursts ofγ discharges. The increase in a reflex activity was accompanied by rigidity, which manifested itself by the appearance of tonic muscle activity. Tremorine and oxotremorine-induced tremor was depressed by the antitremor agents metixene and Kr 339, the antiparkinson drugs atropine and biperiden, and the adrenergicβ receptor blocking agents propranolol and pronethalol. The adrenergicα. receptor blocking agents azapetine, dihydroergotamine, haloperidol, phenoxybenzamine and phentolamine failed to inhibit tremor activity. Chlorpromazine, however, as well as procaine, verapamil and DOPA, diminished the intensity of tremor activity without blocking the generation of tremor bursts. Drugs which depressed tremor activity also antagonized the effect of oxotremorine onα andβ motor activity, whereas the drugs, which only diminished tremor intensity, depressed the increasedα reflex discharge without reducing spontaneousγ activity. Rigidity disappeared whenα reflex discharge was normalized. It is concluded that experimental parkinsonlike rigidity may be interpreted in terms of a disturbed balance between monoaminergic and cholinergic mechanisms in the brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00997117
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