ISSN:
1440-1681
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
1. The drugs used in the treatment of rheumatoid arthritis (RA) form a diverse group with unpredictable adverse effects, mostly weak efficacy and variable responses. Despite their differences, a common feature of many anti-inflammatory and disease-modifying anti-rheumatic drugs (DMARD) is inhibition of pro-inflammatory transcription factors, particularly nuclear factor (NF)-κB and activator protein (AP)-1.2. The present brief review identifies those drugs capable of inhibiting transcription factors, particularly steroids, gold salts, D-penicillamine, cyclosporine A and possibly salicylates.3. The newer biological inhibitors of tumour necrosis factor (TNF)-α and interleukin (IL)-1β are capable of indirect inhibition of NF-κB activation, although even with these potent agents the problem of variability in response has not disappeared.4. The development of selective inhibitors of the transcription factor NF-κB should have the benefit of the anti-inflammatory drugs and DMARD, both new and old.5. It is hypothesized that this strategy will overcome much of the variability in the therapeutic response and adverse effects that limit the usefulness of the exisiting drugs in the treatment of RA.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1046/j.1440-1681.2000.03216.x
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