ZIB

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Sortierung

Digitale Medien

The pharmacokinetics of a new radiosensitiser, Ro 03-8799 in humans (1984)

Allen, J. G. ; Dische, S. ; Lenox-Smith, I. ; [weitere]

Springer

European journal of clinical pharmacology 27 (1984), S. 483-489

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-1041

Schlagwort(e): radiosensitiser ; pharmacokinetics ; healthy volunteers ; tumour patients ; Ro 03-8799

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary A new hypoxic cell radiosensitiser, Ro 03-8799 has been administered intravenously to human volunteers and its kinetic parameters derived from plasma and urine data. Good penetration of drug into tumour tissue is found, consistent with its large volume of distribution. The plasma clearance of this compound is rapid due to high metabolic and renal clearances. These parameters combine to produce an elimination half-life of 5.6 h, approximately half that of misonidazole, a well studied radiosensitiser. It is hoped that this decrease in total body exposure will also reduce the cumulative toxicity seen when misonidazole is administered repeatedly.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00549599

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 1 | 1 Treffer