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  • 1
    Digitale Medien
    Digitale Medien
    Insulin secretory patterns and blood glucose homeostasis after islet allotransplantation in IDDM patients: comparison with segmental- or whole-pancreas transplanted patients through a long term longitudinal study (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 133-139 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Key words Islet transplantation ; Pancreas transplantation ; Arginine test ; IVGTT ; OGTT ; Metabolic profiles ; Serum insulin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract IDDM patients undergoing islet, segmental pancreas or whole pancreas allotransplantation were studied at regular intervals after surgery (3–6 months, 1, 2, 3 and 4 years) to evaluate glycometabolic control (24 h metabolic profile, OGTT) and serum free insulin response to insulinogenic stimuli (arginine, IVGTT). Patients received the same immunosuppressive therapy, based on cyclosporin, steroids and azathioprine. Islet transplanted patients showed: 1) an early peak of insulin secretion after arginine, that was maintained up to 4 years; 2) an early, but low peak of insulin secretion after IVGTT, which was lost at 3 years, despite evidence that islets were still functioning (insulin independence with normal HbA1c levels); 3) a diabetic-like response to OGTT at 3 months, which improved at 2 years (IGT response); 4) fasting euglycemia with mild and reversible post-prandial hyperglycemia during the 24 h metabolic profile, which was maintained for up to 2 years. Insulin secretory patterns of islet transplanted patients were similar to segmental pancreas transplanted patients, and lower than whole pancreas transplanted patients. The reduced beta cell mass transplanted and the functional denervation of the transplanted islets seem to be the major determinants of this behaviour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001090050321
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  • 2
    Digitale Medien
    Digitale Medien
    Lipoprotein profile after combined kidney-pancreas transplantation in insulin-dependent diabetes mellitus (1995)
    Springer
    Transplant international 8 (1995), S. 190-195 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Lipoprotein profile, pancreas transplantation ; Kidney-pancreas transplantation, lipoprotein profile ; Pancreas-kidney transplantation, lipoprotein profile
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In order to evaluate the effect of a combined kidney-pancreas (KP) transplantation in insulin-dependent diabetes mellitus (IDDM) patients on the lipid and lipoprotein profile, 15 KP patients were compared with 11 kidney (K)-transplanted IDDM patients, 19 IDDM patients on hemodialysis (HD), and 15 nondiabetic control subjects. Cholesterol, triglycerides, apo AI, and apo B were measured in total plasma and in VLDL, LDL, and HDL of all participants. VLDL-cholesterol, VLDL-triglycerides, and VLDL-apo B were significantly lower in KP patients, but not in K patients, than in HD patients. In addition, patients in the K, but not in the KP, group showed high levels of apo B in LDL and an increased triglyceride/apo B ratio in VLDL, compared with patients in the HD group. The percentage of apo AI associated with HDL was significantly higher in both transplanted groups than in the HD group. However, compared with a nondiabetic control population, an increase in VLDL particles and in triglyceride content in LDL and HDL still persisted following combined KP transplantation. Insulin resistance (probably due to steroid therapy) associated with high peripheral and potentially low hepatic insulin levels (due to the systemic drainage of the transplanted pancreas) could be the main causes of the remaining lipoprotein abnormalities.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00336536
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  • 3
    Digitale Medien
    Digitale Medien
    Octreotide administration in the treatment of pancreatic fistulae after pancreas transplantation (1992)
    Springer
    Transplant international 5 (1992), S. 201-204 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Pancreas transplantation, fistula ; Fistula, pancreas transplantation ; Octreotide, fistula, pancreas transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Among the surgical complications of pancreas transplantation are pancreatic fistulae, which arise rather frequently. Suppression of exocrine secretion with polymers has succeeded in reducing the rate of this complication. Nevertheless, in some instances, pancreatic fistulas may occur. Thirty pancreas transplantations were performed in 27 diabetic patients. In 5 cases a pancreatic fistula occurred and was drained after the insertion of a catheter for the collection of secretions. A serous liquid was collected with a high concentration of amylases (61604±19562 IU/24h). Fistula output was 280 ±87 ml/24 h. Patients were treated with octreotide, administered subcutaneously in a dose of 300–750 μg/day. In all patients a progressive reduction in fistula output was observed after a mean of 16+2 days. Fistula flow rate dropped to 24±10 ml/24 h-areduction of 95%±5% and drainage was subsequently stopped. Sonographic followup did not show recurrence of peripancreatic collections in these patients. All patients were insulin-independent up to 12–44 months after surgery.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00336070
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  • 4
    Digitale Medien
    Digitale Medien
    Soluble Antiapoptotic Molecules and Immune Activation in Chronic Heart Failure and Unstable Angina Pectoris (2000)
    Springer
    Journal of clinical immunology 20 (2000), S. 101-106 
    Details
    ISSN: 1573-2592
    Schlagwort(e): Apoptosis ; chronic heart failure ; unstable angina pectoris ; soluble Fas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Programmed myocyte cell death and activation of the immune system have been shown to occur in patients with congestive heart failure. Besides, unstable angina episodes are likely to be associated with immune activation. Our aim was to evaluate the role of changes in circulating levels of soluble Fas (sFas), suggestive of an enhanced inhibitory response to ongoing apoptosis, and soluble IL2 receptor (sIL2-R), indicative of T-lymphocyte activation, in chronic heart failure and unstable angina pectoris. Thirty patients affected by chronic heart failure (20 idiopathic and 10 ischemic cardiomyopathy) and 13 patients with unstable angina were evaluated. Twenty healthy individuals matched for age and gender were used as controls. A complete biochemical determination of indexes of myocardial damage including cardiac troponin I (cTnI) and creatine kinase (MB/CK) was performed. The results demonstrated that mean levels of sFas and sIL2-R were significantly increased in patients affected by chronic heart failure and unstable angina and were not associated with changes in renal function or with serum levels of cTnI. Highest values of sFas were found in NYHA class IV patients (IV NYHA class = 7.39 ± 0.52 vs. controls = 1.34 ± 0.12 ng/ml; P 〈 0.01) and more elevated in idiopathic than in ischemic cardiomyopathy (3.64 ± 0.40 vs. 1.82 ± 0.37 ng/ml; P 〈 0.01). Moreover, in chronic heart failure patients sFas and ejection fraction were negatively correlated (P = 0.01), whereas sFas and sIL2-R were positively correlated (P 〈 0.01). In unstable angina patients too, sFas and sIL2-R appeared to be correlated (P = 0.03); whereas sFas (angina group = 3.18 ± 0.39 vs. controls = 1.34 ± 0.12 ng/ml; P 〈 0.01) and sIL2-R (angina group = 0.46 ± 0.11 vs. controls = 0.00 UI/ml; P 〈 0.01) were higher in angina group than in controls. In most of the cases, the increase of sFas was associated with comparable changes in sIL2-R serum levels, indicating that the activation of Fas system is strictly associated with autoimmune–inflammatory reactions. This phenomenon, both in chronic heart failure and in unstable angina, occurs in the absence of biochemical evidences of myocardial damage and seems to parallel the activation of T cell. Soluble Fas could have a role in sustaining inflammatory response and in prolonging the detrimental effects correlated with it in chronic heart failure and angina pectoris.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006630429764
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  • 5
    Digitale Medien
    Digitale Medien
    Cyclosporine-A in the treatment of serpiginous choroiditis (1990)
    Springer
    International ophthalmology 14 (1990), S. 395-399 
    Details
    ISSN: 1573-2630
    Schlagwort(e): Serpiginous choroiditis ; geographic choroidopathy ; Cyclosporine-A in uveitis ; immunosuppression in uveitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Seven patients affected by bilateral inflammatory serpiginous choroiditis have been treated with Cyclosporine-A for 6-21 months. Nine outof the fourteen eyes showed a significant improvement in their visual acuity; five eyes did not change. Cyclosporine-A may, therefore, be considered effective in the treatment of this disease. Its usefulness seems to be greater when the serpiginous choroiditis is in its ‘acute’ stage; ‘chronic’ stages, however, also seem to improve under treatment. Its main indication is, in our opinion, the involvement of the macular region of the ‘second’ eye, when the ‘first’ eye is already damaged. We consider Cyclosporine-A, in these situations, to be a first choice treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00163565
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