ISSN:
1435-232X
Schlagwort(e):
Key words Huntingtin interacting protein (HIP1)
;
Leucine zipper
;
Chromosome 12q24
;
Full-length enriched cDNA library
;
Neuroblastoma
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Huntington disease (HD) is an inherited neurodegenerative disorder which is associated with CAG expansion in the coding region of the gene for huntingtin protein. Recently, a huntingtin interacting protein, HIP1, was isolated by the yeast two-hybrid system. Here we report the isolation of a cDNA clone for HIP1R (huntingtin interacting protein-1 related), which encodes a predicted protein product sharing a striking homology with HIP1. RT-PCR analysis showed that the messenger RNA was ubiquitously expressed in various human tissues. Based on PCR-assisted analysis of a radiation hybrid panel and fluorescence in situ hybridization, HIP1R was localized to the q24 region of chromosome 12.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s100380050087
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