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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 41 (1985), S. 348-350 
    ISSN: 1420-9071
    Schlagwort(e): Chlamydocin ; HC-toxin ; phytotoxin ; cytostatic agent
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide α-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.
    Materialart: Digitale Medien
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  • 2
    ISSN: 1432-1238
    Schlagwort(e): Key words Histamine ; Protein permeability ; Measurements technique ; Indocyanine green ; Glucose
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: The plasma volume of histamine-induced protein capillary leakage may be overestimated when this is determined using the indocyanine green (ICG) dilution method (Vd-ICG), since this dye binds to plasma proteins. The initial distribution volume of glucose (IDVG) has been shown to indicate the central extracellular fluid volume including plasma. Accordingly, the overestimation would be detected by a higher Vd-ICG/IDVG ratio. Our study was intended to examine whether the simultaneous measurement of these two variables can evaluate histamine-induced protein leakage and associated hypovolaemia. Design: Prospective animal study. Setting: Institutional animal research laboratory. Subjects: Twenty-four anaesthetized and ventilated mongrel dogs. Interventions: Anaesthetized animals were mechanically ventilated and received infusions of normal saline (n = 8), histamine 50 μg/kg per h (n = 8), or histamine 100 μg/kg per h. The Vd-ICG and IDVG were calculated using a one-compartment model by simultaneous administration of ICG 0.5 mg/kg, and glucose 100 mg/kg followed by serial arterial blood sampling. Measurements and results: In both histamine groups, a significant elevation of haematocrit and a decrease of plasma albumin concentration were found (p 〈 0.05). Although the IDVG decreased following histamine administration (p 〈 0.05), the Vd-ICG remained unchanged. The Vd-ICG/IDVG ratio increased in a dose-dependent manner after histamine administration (p 〈 0.05), but remained unchanged following normal saline administration. Conclusion: The results suggest that the Vd-ICG/IDVG ratio and the IDVG are useful in evaluating the magnitude of the leakage and hypovolaemia.
    Materialart: Digitale Medien
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  • 3
    ISSN: 1432-0797
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract Production of t-PA by human embryonic lung fibroblasts, IMR-90 cells, is regulated by negative feedback control. The increase in the concentration of the extracellular t-PA lead to a reduction of the production. Therefore, we investigated the application of t-PA adsorption column to ceramic bed reactor to promote t-PA production. Amberlite XAD-8 was selected out as an adsorbent, because it is autoclavable and can adsorb 32,000 IU of t-PA per g wet gel. The t-PA adsorption column was located in the medium recirculation line to the vessel. On the other hand, medium was recirculated between the ceramic bed reactor and the vessel using another flow line. The bioreactor system with the adsorption column was about 2.5 times higher with the resulting cumulative t-PA than that without the adsorption column.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Applied physics 59 (1994), S. 579-582 
    ISSN: 1432-0630
    Schlagwort(e): 42.65 ; 42.70 ; 72.40
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract Two-beam coupling gain and speed of a Cr-doped strontium-barium niobate single crystal at 514.5 nm and 632.8 nm are measured to compare photorefractive origins and responses. The same single deep center and single carriers are found to be responsible for the observed photorefractivities at both wavelengths. Self-pumped phase-conjugate reflectivities are also measured at both wavelengths.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Acta neurochirurgica 118 (1992), S. 91-97 
    ISSN: 0942-0940
    Schlagwort(e): Anterior communicating artery ; aneurysm ; early surgery ; operative approach
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We reviewed the surgical outcome in 85 patients with ruptured anterior communicating artery (ACoA) aneurysms, who were operated on within 72 hours of onset via a basal interhemispheric (BIH) approach (Group 1, N=48), or an anterior interhemispheric (AIH) approach (Group 2, N=37). The age, sex ratio and pre-operative grade (Gr) were similar for both groups. The outcome at the time of discharge was as follows for group 1: excellent or good 88%; fair, 6%; vegetative state, 2% and death 4%. For group 2, it was: excellent or good 78%; fair, 16%; vegetative state, 3%; and death, 3%. A significant correlation between admission grade and outcome was found in both groups. The outcome in group 1 was better than in group 2 for patients with a Glasgow Outcome Scale (GOS) better than fair (p 〈 0.07). No patient in group 1 had postoperative anosmia, but nine patients in group 2 became anosmic. The total number of complications was also significantly less in group 1. Our overall mortality rate was 4%. In conclusion, the BIH approach was more beneficial for treating acute ACoA aneurysm.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Acta neurochirurgica 63 (1982), S. 53-58 
    ISSN: 0942-0940
    Schlagwort(e): Vasospasm ; somatosensory evoked potentials ; brain function
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Somatosensory evoked potentials (SEP) were recorded in 9 patients with vasospasm caused by subarachnoid haemorrhage. There was a correlation between SEP changes and clinical outcome evaluated one month after onset. And, evaluation of SEP changes under induced hypertension or infusion of dehydrates was available to study the nature of ischaemic brain dysfunction caused by vasospasm. Furthermore, this study suggests that the available period of induced hypertension may be short in cases with severe clinical outcomes.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Acta neurochirurgica 63 (1982), S. 111-116 
    ISSN: 0942-0940
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of subarachnoid haematoma (clot) evacuation for the prevention of vasospasm (VS) in the acute stage was studied using 62 ruptured IC and MC aneurysm cases. Extensive clot evacuation within 48 hours after the onset did not prevent the development of VS but reduced the severity of VS, especially in the main trunks of the cerebral arteries (IC, M1, M2, A1). But excessive clot evacuation applied to the angry, swollen brain in the acute stage worsened the brain swelling and sometimes formed an intracerebral haematoma due to brain compression. The extent of the clot evacuation should be determined by preoperative CT findings and the brain's condition during the operation.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Acta neurochirurgica 124 (1993), S. 71-78 
    ISSN: 0942-0940
    Schlagwort(e): Ischaemic cerebrovascular disease ; unruptured intraeranial aneurysm ; surgical indications ; results ; subarachnoid haemorrhage
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Out of 3435 patients with ischaemic cerebrovascular disease 2540 cases were investigated using cerebral angiography. In 127 of them (5%) aneurysms were found, but without clinical evidence of subarachnoid haemorrhage (SAH). 45 cases were operated upon and 82 were treated conservatively. Five of these 82 cases (6%) suffered from SAH 3 months to 10 years (mean interval 5,6 years) after the angiographic diagnosis. Four of these 5 patients with SAH died. Among the 45 surgical cases follow-up was uneventful in 29 (64%). The other 16 cases postoperatively showed neurological deterioration (36%), which was transient in 6 but with only minor improvement in 10. Of these 10 cases 2 died from cerebral infarction related to intra-operative temporary vascular occlusion respectively myocardial infarction. Thus surgical mortality was 4% and permanent morbidity 18%. Causes of postoperative neurological deterioration were partly related to general arteriosclerotic changes and special fragility of the ischaemic brain, and partly to operative technique (excessive brain retraction, damage to cortical veins, occlusion of major vessels or damage to perforators, temporary artery occlusion). Apparently in cases with ischaemic cerebrovascular diseases operative procedures, which in other cases as a rule are well tolerated, may produce harmful effects. Therefore, in these cases, the indication for operative treatment of so far silent aneurysms should be restricted to patients who are in good general condition with longer life expectancy as far as the vascular disease is concerned, and without major neurological deficit. Furthermore, the operative technique should be especially gentle and atraumatic.
    Materialart: Digitale Medien
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  • 9
    ISSN: 0942-0940
    Schlagwort(e): Keywords: Hypothermia; cerebral aneurysm; subarachnoid haemorrhage; positron emission tomography.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary ¶ Cerebral blood flow and O2 metabolism during hypothermia (33–34°C) was evaluated in 5 patients with aneurysmal subarachnoid haemorrhage by positron emission tomography (PET). Their preoperative clinical condition was WFNS scale IV or V. The patients received surface cooling postoperatively, and were maintained in a hypothermic state during transfer for radiological examination. Positron emission tomography revealed a decrease in cerebral blood flow and O2 metabolic rate. Cerebral blood flow was 34.8±15.1 ml/100ml/min and the O2 metabolic rate was 1.85±0.61 ml/100ml/min in areas of the middle cerebral artery ipsilateral to the ruptured aneurysms, whereas these values were 30.8±7.1 and 2.21±0.45 ml/100ml/min, respectively, on the contralateral side. This represents a decrease of 37±27% compared to normal cerebral blood flow and 52±16% compared to normal O2 metabolic rate (p〈0.02) in the ipsilateral areas, and decreases of 44±13% and 43±12%, respectively, on the contralateral side. The present results reflected the luxury perfusion state in almost all cases and provide the first PET evidence of decreased cerebral blood flow and metabolic rate of O2 during hypothermia in humans.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Acta neurochirurgica 63 (1982), S. 163-174 
    ISSN: 0942-0940
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have managed 674 cases of ruptured aneurysms of the anterior part of the circles of Willis during the period 1969 to 1980. For this study, analyses were made to clarify the operative indication, timing and suitable procedures based on the pathophysiology of severe cases in the acute stage. Clinical results of conservative treatment in the era of delayed operation clearly show the inevitable necessity of early operation. The CBF measurement in the acute stage revealed a slight decrease of hemispheric CBF without regulatory dysfunction of cerebral circulation within 3 days of SAH. Results of early operation within 3 days of SAH in the 3rd era showed that 83.1% of cases survived with a good outcome and 3.4% died when they were in Grades 1 and 2. 40 cases with severe grading, operated on within 3 days of SAH, were studied on each site of the aneurysm. Mortality was 12.5% and there was a favourable outcome in 55%. Death was due to brain swelling caused by vasospasm and direct brain damage caused by SAH and an intracerebral haematoma. Extensive evacuation of subarachnoid clotting could be performed only when brain volume could be reduced enough to minimize brain compression, by using ventricular drainage, evacuation of the intracerebral haematoma and Mannitol administration. Surgical procedures for each aneurysm are also described.
    Materialart: Digitale Medien
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