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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Cancer chemotherapy and pharmacology 40 (1997), S. 419-424 
    ISSN: 1432-0843
    Schlagwort(e): Key words Anthracyclines ; Hypothermia ; Chlorpromazine ; Pharmacokinetics ; Mice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Blood concentrations of doxo- and epirubicin were studied in mice after i.v. or i.p. administration under normal and hypothermic conditions. The animals either were pretreated i.p. with chlorpromazine at 15 mg/kg and allowed to cool to a rectal temperature of 28 °C or were given saline i.p. with their rectal temperature remaining at 37 °C. The anthracyclines were 14-14C-labeled and were given at a dose of 0.85 mg/kg. Blood samples were taken at 5, 15, and 25 min and 2, 6, 24, and 48 hours after injection and were analyzed by liquid scintillation counting. The blood concentration related to time was similar for the two anthracyclines. The peak concentration was highest for i.v. administration and was higher for the hypothermic groups. The peak concentration and the area under the curve were highest under hypothermic conditions. The terminal half-life was longer after i.p. administration. The ratio calculated for the blood concentration under hypothermic/normothermic conditions over time was substantially increased after i.p. administration, the increase being most pronounced for epirubicin. The pharmacokinetic characteristics found might be related to the anthracycline toxicity encountered in tumor-inoculated mice treated at different body temperatures.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract The results of a one-year study of the total air-borne14C effluents from two Swedish light-water reactors, one boiling water reactor (BWR) at Forsmark and one pressurized water reactor (PWR) at Ringhals, are presented. Air emitted from the stacks has been collected continuously over two-week periods and the14C content in the samples has been analysed using accelerator mass spectrometry (AMS). The14C activity concentration in the air issuing from the stack of the PWR varied between 2 and 1132 Bq/m3 with a mean value of 200 Bq/m3, while from the BWR the activity concentration varied between 4 and 146 Bq/m3, with a mean value of 95 Bq/m3. The corresponding14C release rate was 0.27 TBq/GWel·year for the PWR and 0.48 TBq/GWel·year for the BWR. During the same period of time, for comparison, the14C activity in continuously collected air from the stack of the PWR was also measured by liquid scintillation counting. In most cases the results of these measurements were in fair agreement with the corresponding AMS results.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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