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  • Artikel: DFG Deutsche Nationallizenzen  (3)
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  • Artikel: DFG Deutsche Nationallizenzen  (3)
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  • 1
    Digitale Medien
    Digitale Medien
    072
Wound Healing Properties of Reconstituted Freeze-Dried Platelets (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The use of fresh platelets has gained value in medicine as an essential part of wound treatments. This is not surprising since platelets contain a number of bioactive factors that contribute to the process of wound healing, such as platelet-derived growth factor (PDGF) and transforming growth factor (TGF). Fresh platelets’ short shelf life limits platelet-based therapies. If platelets can be stabilized in freeze-dried form (FDP) then long-term storage as well as pathogen inactivation methods become possible. Adlyfe and Oregon Freeze-Dry have been developing technology to stabilize freeze-dried human platelets that can be subjected to gamma irradiation and stored for a long duration. Upon reconstitution, irradiated FDP retained growth factors PDGF-AB, PDGF-BB, and TGF-B1 in quantities similar to fresh platelets as judged by capture ELISA. The rehydrated FDP promoted new DNA synthesis and cellular proliferation of primary human dermal fibroblasts and endothelial cells (HUVECs) similar to fresh platelets. The FDP also promoted remodeling of extracellular matrix by accelerating fibroblast-mediated contraction of collagen gels and stimulated HUVECs to undergo angiogenesis and form capillary structures in vitro. Therefore, we conclude that FDP and fresh platelets have comparable in vitro wound healing potential. Preclinical wound healing stud"ies in diabetic mice are under way and further development will allow FDP to be a safe and well-suited alternative to fresh platelets for wound healing applications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215bt.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    THE ARCHAEOLOGY OF THE AFRICAN DIASPORA (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Anthropology 27 (1998), S. 63-82 
    Details
    ISSN: 0084-6570
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Ethnologie , Biologie
    Notizen: Abstract Archaeologists currently studying the African diaspora generally examine three broad issues, in decreasing order of prominence: the material identification of African identity, the archaeology of freedom at maroon sites, and race and racism. While conducting this research, several scholars have learned that many nonarchaeologists are deeply interested in their interpretations. At the present time, the archaeology of the African diaspora is not a truly global pursuit and the New World is overrepresented. This situation should change as archaeologists around the world discover post-Columbian archaeology and take up diasporic investigations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.anthro.27.1.63
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Molecular analysis of pentachlorophenol degradation (1994)
    Springer
    Biodegradation 5 (1994), S. 277-288 
    Details
    ISSN: 1572-9729
    Schlagwort(e): Pentachlorophenol ; biodegradation ; dechlorination ; dehalogenation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Energietechnik , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract A limited number of microorganisms have been described for their ability to partially degrade pentachlorophenol (PCP), or to completely mineralize it. Several years ago we chose one of these microorganisms,Flavobacterium sp. strain ATCC 39723, for use in a detailed molecular analysis of the catabolism of PCP. This strain was chosen because it had previously been studied in great detail for its growth characteristics in relation to degradation of PCP. In this paper we provide an overview of the degradation pathway of PCP to 2,6-dichloro-p-hydroquinone byFlavobacterium. The specific biochemical reactions and the genes encoding the enzymes are reviewed. The successful transformation and site specific mutagenesis ofFlavobacterium, as well as the discovery of two newpcp alleles is also presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00696465
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