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Digitale Medien

An origin in the local Universe for some short γ-ray bursts (2005)

Chapman, R. ; Levan, A. J. ; Priddey, R. S. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 438 (2005), S. 991-993

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Gamma-ray bursts (GRBs) divide into two classes: ‘long’, which typically have initial durations of T90 〉 2 s, and ‘short’, with durations of T90 〈 2 s (where T90 is the time to detect 90% of the observed fluence). Long ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nature04310

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Digitale Medien

Review article: current management of primary sclerosing cholangitis (2005)

Cullen, S. N. ; Chapman, R. W.

Oxford, UK : Blackwell Science Ltd

Alimentary pharmacology & therapeutics 21 (2005), S. 0

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ISSN: 1365-2036

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: The management of primary sclerosing cholangitis (PSC) is hindered by incomplete understanding of the pathogenesis of the disease and the lack of good prognostic models. Few large randomized controlled trials of drug therapy have been published. Best practice in the management of PSC is currently based therefore on careful interpretation of the available evidence, close observation of individual patients and clinical experience of the disease. Drug therapy is useful for alleviating symptoms. Ursodeoxycholic acid may slow progression of the disease and reduce the frequency of complications. Consensus is emerging on the issues of screening for the malignant complications of PSC and the indications for liver transplantation are becoming broader and encompassing the earliest stages of cholangiocarcinoma. In view of the rarity of the disease in the general population, large international collaborations to study PSC are necessary to provide clearer answers in areas of uncertainty, and these are now beginning to emerge.