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  • 1985-1989  (3)
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  • 1
    Digitale Medien
    Digitale Medien
    Pharmacodynamics, pharmacokinetics and metabolism of digitoxin and derivatives in cats (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 335 (1987), S. 469-475 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Digitoxin ; Digitoxin-derivatives ; Therapeutic margin ; Pharmacokinetics ; Metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Derivatives of dihydro-digitoxin (DHD) were studied in the search for a glycoside with a primarily extra-renal clearance and a faster elimination rate than digitoxin. The positive inotropic doses of the derivatives of DHD were higher than those of digitoxin and digoxin. There was no significant difference in the therapeutic margin. After injection of 3H-digoxin in unaesthetized cats, no metabolites were found in the serum which did not bind with the antibody used for the RIA. After injection of 3H-digitoxin, and its derivatives, the radioactivity was cleared from the serum at a much lower rate than the concentrations assayed by RIA. The metabolites which did not bind to the digitoxin antibody were hydrophilic and had a low protein binding. Digitoxin-bisdigitoxoside (Dt-2) determined by RIA rapidly disappeared from the serum. The radioactivity remaining after 24 h was eliminated with a half-life of 219 h. Ten min after injection of DHD the serum contained no unchanged DHD, but 36% digitoxin suggesting that the reduction of digitoxin to DHD is reversible and that the conversion of DHD to Dt-2 is the rate limiting step in the metabolism of digitoxin. The total body clearance of digitoxin, its metabolites and derivatives determined by RIA increased in the order DHD-oxime ⩽ digitoxin 〉 DHD ⩽ DHD-acetyloxime 〈 DHD-methyloxime. The clearance and the elimination rate of DHD-methyloxime were significantly higher than those of digitoxin (P = 0.05).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00165565
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  • 2
    facet.materialart.
    Unbekannt
    Die Herausbildung und Entwicklung der Geschichtsauffassung von Engels zwischen 1839 und 1842 (1987)
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 35:11 (1987) 1006 
    Details
    ISSN: 0012-1045
    Thema: Philosophie
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1987-035-11-000004
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  • 3
    Digitale Medien
    Digitale Medien
    Crossovers in two German cystic fibrosis families determine probe order for MET, 7C22 and XV-2c/CS.7 (1987)
    Springer
    Human genetics 〈Berlin〉 77 (1987), S. 197-199 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary We have followed the segregation of the probes pJ3.11, 7C22, pB79a, and MET through cystic fibrosis families in the German Democratic Republic with two affected sibs. Two families with a crossover between MET and the CF phenotype were detected. In one of these families recombination was also observed between the DNA probe 7C22 and CF, and between the markers XV-2c and CF, which suggests that XV-2c, MET and 7C22 are all on the same side of CF. The other MET recombinant family is informative with XV-2c and does not recombine, which excludes the genetic order XC-2c-MET-CF if multiple recombinant events are disregarded. These two families together demonstrate that recombinations may occur in a very small genetic interval, which has important implications for prenatal diagnosis based on data from linked markers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00272392
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