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  • 1975-1979  (9)
  • 1970-1974  (11)
  • 1960-1964  (1)
  • 1955-1959  (1)
  • 1
    Digitale Medien
    Digitale Medien
    ANTIARRHYTHMIC PROPERTIES OF 5-(3-TERT-BUTYLAMINO-2-HYDROXY)PROPOXY-3,4-DIHYDRO-CARBOSTYRIL HYDROCHLORIDE (OPC- 1085), A NEWLY SYNTHESIZED, POTENT β-ADRENORECEPTOR ANTAGONIST (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The antiarrhythmic properties of 5–(3-tert-butylarnino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085) were compared with those of propranolol and pindolol using various kinds of preparations for experimental arrhythmia in dogs.2. Although OPC-1085 was the most potent drug to antagonize adrenaline-induced arrhythmia in animals anaesthetized with either pentobarbitone sodium or halothane, it was scarcely effective on ouabain-induced arrhythmia in pentobarbitone sodium anaesthetized animals.3. When these compounds were administered intravenously to conscious dogs 24 h after two-stage ligation of the anterior descending artery, ectopic ventricular beats of coronary ligation-induced arrhythmia were reduced while regular sinus beats were simultaneously increased.4. OPC-1085 was very effective on aconitine-induced arrhythmia in dogs anaesthetized with pentobarbitone sodium. The effective dose was similar to that of propranolol but about fifteen times less than that of pindolol.5. It is concluded that different potencies among these β-adrenoreceptor antagonists against various kinds of experimental arrhythmias cannot be simply deduced from any one of the following properties; β-adrenoreceptor antagonism, intrinsic myocardial stimulation, local anaesthetic and so-called quinidine-like effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02684.x
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  • 2
    Digitale Medien
    Digitale Medien
    Chemical Properties of Amorphous Metals (1978)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Materials Research 8 (1978), S. 215-233 
    Details
    ISSN: 0084-6600
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.ms.08.080178.001243
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  • 3
    Digitale Medien
    Digitale Medien
    EFFECTS OF GLUCAGON ON PANCREATIC SECRETION IN THE DOG (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The effects of glucagon on the secretion of pancreatic juice were investigated using blood-perfused canine pancreas preparations.2. Intravenous administration of glucagon (3–30 μg/kg) to the donor dog elicited a dose-dependent increase in pancreatic secretion. Intra-arterial administration of glucagon (10–100 μg) into the perfused pancreas also elicited increased secretion.3. There were slight increases in amylase concentration of the pancreatic juice with the largest doses of glucagon given by either route.4. Glucagon-induced secretion was not modified by treatment with phentolamine, propranolol, atropine, guanethidine, tetrodotoxin, haloperidol, prostaglandin F2a or calcitonin.5. The results suggest that glucagon acts directly on the exocrine cells of the canine pancreas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00591.x
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  • 4
    Digitale Medien
    Digitale Medien
    EFFECT OF DEPLETION OF SERUM CALCIUM BY EGTA ON CANINE PANCREATIC SECRETION INDUCED BY DOPAMINE AND BY SECRETIN (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY 1. Pancreatic secretion has been monitored in the isolated, blood-perfused canine pancreas, and the effects of depletion of serum calcium by infusion of EGTA on the increases in secretion produced by intra-arterial injections of dopamine and secretin have been investigated.2. Under resting conditions in preparations in dogs fasted for 24 h, the mean rate of pancreatic secretion was 16.4 μ1/min (s. e. m. = 2, n= 12). The mean concentrations of protein, bicarbonate and chloride in the pancreatic juice were 53.8 mg/ml (s. e. m. = 4.5), 18.0 mmol/1 (s. e. m. = 1.1) and 122.5 mmol/1 (s. e. m. = 7.5), respectively. Infusion of EGTA had no effect on resting secretion.3. Secretion elicited by dopamine or secretin was diminished about 50% during the intra-arterial infusion of EGTA (10−2 mM/ml) in the perfusing blood. The protein concentration in the secretion was diminished to a similar extent. The concentrations of bicarbonate and chloride in the pancreatic juice was not modified by EGTA infusion.4. Concomitant infusion of an equimolar concentration of CaCl2 solution abolished the inhibitory effects of EGTA infusion on the secretory responses to dopamine or secretin.5. The results suggest that dopamine and secretin influence the exocrine secretions of the pancreas by actions on both acinar and ductular cells. Acinar cell secretion is more susceptible to depletion of serum calcium levels than is secretion from ductular cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00551.x
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  • 5
    Digitale Medien
    Digitale Medien
    EFFECTS OF CALCITONIN ON THE SECRETION OF PANCREATIC JUICE INDUCED BY DOPAMINE, SECRETIN AND PANCREOZYMIN (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Effects of calcitonin on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated blood-perfused canine pancreas.2. The volume of pancreatic secretion induced by pancreozymin given intra-arterially (i.a.) was decreased by an i.a. infusion of 1 u/min of calcitonin, but that induced by dopamine or secretin given i.a. was not affected by calcitonin treatment.3. Amylase concentration in pancreatic juice either in spontaneous secretion in the resting state or in that of stimulated secretion by pancreozymin was decreased approximately 30% by calcitonin treatment, but amylase concentration in pancreatic juice induced by dopamine or secretin was not affected by calcitonin treatment.4. Calcitonin had no effect on bicarbonate concentration in pancreatic juice stimulated by these secretagogues.5. Calcium concentration in pancreatic juice in the resting state was reduced about 36% by calcitonin treatment. Calcitonin caused a decrease in a calcium concentration in the pancreozymin-induced secretion, but did not cause any change in the dopamine- or secretin-induced one.6. These results suggest that calcitonin may affect the secretory mechanism of the acinar cells but not that of the ductular cells, and that the acinar cells are active even in the resting state.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00600.x
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  • 6
    Digitale Medien
    Digitale Medien
    Two Hæmoglobins in Chum Salmon (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 1418-1418 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The present communication deals with crystallization and several properties of the two components. Haemolyzate from chum salmon blood saturated with carbon monoxide, was 0-35 saturated with ammonium sulphate at neutral pH and suctioned. The nitrate was 0-6 saturated with the salt and the resulting ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/1841418a0
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  • 7
    Digitale Medien
    Digitale Medien
    The chemoreflex induced by intraarterial injection of Aza-azepinophenothiazine, veratridine and bradykinin into femoral and brachial arteries of innervated and divided limbs of a dog (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 394-396 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Reflektorische Blutdrucksteigerung wurde durch intraarterielle Injektion von Tetrahydro-azaazepinophenothiazin und Veratridin am Präparat des innervierten Hinterbeins vom Hund hervorgerufen. Während kleine Dosen von Bradykinin nur leichte Blutdrucksenkung verursacht, führen grössere Dosen zu nachhaltigem Blutdruckanstieg. Bei Abhäuten des Hinterbeinpräparates unterblieb der Primäreffekt.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02147987
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  • 8
    Digitale Medien
    Digitale Medien
    Comparison of newβ-adrenergic blockers, C-3, Kö1366, Y-6124 and YB-2, with pindolol and propranolol in the blood perfused canine papillary muscle preparation (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 813-814 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Es wurde die Potenz sechs β-adrenergischer Blockierungsmittel auf positiv inotrope Wirkung von Noradrenalin am isolierten, Blut zuführenden Papillarmuskel des Hundes vergleichend untersucht. Die Reihenfolge der Wirksamkeit: Köl366〉pindolol〉C-3〉Y-6124=YB−2 = propranolol (30:10:5:1)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923147
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  • 9
    Digitale Medien
    Digitale Medien
    Comparison of β-adrenergic blocking activity of eight blockers in the excised and blood-perfused canine sino-atrial node preparation (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 822-823 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Mit neu ausgebauter Methode sind 8 ältere und neuere β-Blocker auf ihre Eigenwirkung und ihre Wirksamkeit als Noradrenalin-Antagonisten geprüft worden. Die abgestuften Wirksamkeitszahlen sind: Kö1366 (20)〉Pindolol (10)〉C-3 (5)〉YB-2=Y-6124 (3)〉Propranolol (1)〉Practolol (2/3)〉Sotalol (1/3).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923153
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  • 10
    Digitale Medien
    Digitale Medien
    Antiarrhythmic effects of dichlorisoprenaline, H 56/28, ICI 50172, LB 46, MJ 1999 and propranolol on aconitine-induced atrial and ouabain-induced ventricular arrhythmias (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 666-667 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Der Effekt von sechsβ-adrenergischen Blockierungsmitteln auf Akonitin-Arrhythmia bzw. Ouabain-Arrhythmia wurde mittels i.v. Verabreichung vergleichend untersucht. Reihenfolge der Wirksamkeit auf Akonitin-Arrhythmia: Propranolol〉MJ 1999〉LB 46〉H 56/28, ICI 50172 und DCI, und dieselbe auf Ouabain-Arrhythmia: Propranolol, LB 46 und H 56/28 gleichwertig, MJ 1999 und ICI 50172 wirkungslos.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02136950
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