ISSN:
1433-2981
Schlagwort(e):
Acute phase response
;
Haptoglobin
;
Infection
;
Red deer
;
Yersiniosis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Haematological changes were followed in a field model of infection with Yersinia pseudotuberculosis using female weaver red deer, 109 animals having blood samples taken before the challenge and at various times after challenge, a total of 553 blood samples being processed. Clinical signs first developed 4 days after exposure, with a mode of 5 days and median of 7 days. Neutrophils rose sharply to well above the upper reference limit 1–2 days postexposure, but were within reference limits by days 3 to 4, before the development of clinical signs. Both haptoglobin and fibrinogen levels increased within 24 h of exposure to levels above the reference range, fibrinogen returning to within the reference range about day 14, though still highly significantly raised compared to pre-exposure values. Haptoglobin levels were still greater than the reference range upper limit 28 days after exposure. Mononuclear leucocytes were reduced in number 2 days after exposure reaching a minimum at 4 days and reaching pre-exposure values by day 6. Eosinophil numbers were low at 2 days, all clinical cases having eosinophil counts round the low end of the reference range, counts remaining low and not reaching pre-exposure levels until the 28th day sample. The basophil count decreased in animals with inflammation early in the infection and increased above pre-challenge values around the 28th day. Circulating platelet numbers decreased with a minimum 4 days after exposure, then increased above pre-exposure values from day 6 to day 11. The mean platelet volume was low on day 5, returning gradually towards pre-exposure values, but still low on day 28. Red cell mass indicators were higher and mononuclear leucocytes were lower in fatal cases than in non-fatal clinical cases. Fibrinogen level and neutrophil counts were higher in animals with clinical signs that survived, compared to animals without clinical signs but from which Yersinia were isolated. Subcutaneous injection of killed Yersinia also invoked a neutrophil leucocytosis, reductions in circulating mononuclear leucocyte, eosinophil and basophil numbers, and mean platelet volume. There were also increases in fibrinogen and haptoglobin levels, and in circulating platelet numbers.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00368274
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