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Digitale Medien

Fetal adrenal transplants respond to ACTH and prevent addisonian crisis in adrenalectomized rats (1998)

Till, H. ; Kellnar, S. ; Strassburger, C. J. ; [weitere]

Springer

Pediatric surgery international 13 (1998), S. 271-273

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Details

ISSN: 1437-9813

Schlagwort(e): Key words Fetal transplantation ; Adrenals ; Addisonian crises ; Rat ; Adrenocorticotropic hormone

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The present study investigates whether fetal adrenal transplants into the omentum of adrenalectomized rats will be integrated into the recipient's endocrine system to provide competent adrenocortical function. The results demonstrate that fetal adrenals graft with a rich vascular supply, mature histologically, and produce increasing levels of corticosterone. When bilateral adrenalectomy is performed in the recipient, survival is prolonged and addisonian crisis can be prevented. Moreover, adrenocorticotrophic hormone levels decrease with increasing levels of corticosterone, indicating that the fetal grafts are integrated into the physiological pituitary-adrenocortical feedback system.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s003830050314

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