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Digitale Medien

A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic indices (1993)

Bainbridge, A. D. ; Herlihy, O. ; Meredith, P. A. ; [weitere]

Springer

European journal of clinical pharmacology 45 (1993), S. 425-430

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Details

ISSN: 1432-1041

Schlagwort(e): Amlodipine ; Felodipine ER ; pharmacokinetics ; blood pressure response

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary This study investigated potential therapeutic differences between Amlodipine 5 mg and Felodipine ER 10 mg in 12 normotensive/borderline hypertensive subjects by comparison of the plasma drug concentration-time profiles and the blood pressure and heart rate responses. There was significantly less trough-to-peak variability in plasma drug concentrations with amlodipine with a ratio of 67%, compared to 37% for felodipine. Correspondingly there was less variability with amlodipine in the blood pressure reductions across the dosage interval. Overall, amlodipine displayed a more consistent hypotensive effect across 24 hours and lower blood pressure values at trough, i. e. 24 hours post-dose.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00315513

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