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  • 1
    ISSN: 1435-1463
    Schlagwort(e): Keywords: Wet dog shaking behavior (WDS) ; dehydroepiandroste-rone (DHEA) ; dexamethasone ; (±)-1-(2 ; 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) ; serotonin-2A (5-HT-2A) receptor.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary. It has been reported that dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEA-S) is associated with affective disorders and that pathology of affective disorders are related with dysfunction of serotonin(5-HT)-2A receptor-mediated responses. In this study, we investigated the effect of DHEA on (±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI), 5-HT-2A receptor agonist, -induced wet dog shaking behavior (WDS) in rats. Acute treatment with DHEA inhibited the DOI-induced WDSs dose dependently. This inhibition was recovered by opioid receptor antagonist, naltrexone. 5-HT-2A receptor-mediated WDSs were desensitized after chronic treatment with DOI, however chronic treatment with DHEA had no effect on this desensitization. Chronic treatment with DHEA had no facilitating effect of chronic dexamethasone treatment on DOI-induced WDSs. These findings may lead the possibility that DHEA has the inhibitory effect of 5-HT-2A mediated signaling pathway via non-genomic action.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of applied physiology 73 (1996), S. 511-515 
    ISSN: 1439-6327
    Schlagwort(e): Inhibitory summation of cardiorespiratory response ; Upper limb exercise ; Lower limb exercise
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The purpose of this study was to examine whether cardiorespiratory responses to combined rhythmic exercise (60 contractions · min−1) was affected by different combinations of upper and lower limb exercise in seven healthy women. Six different rhythmic exercises were compared: 6-min rhythmic handgrip at 10% of isometric maximal voluntary contraction (MVC) (H10); 6-min rhythmic plantar flexion at 10% MVC (P10); exhausting rhythmic handgrip at 50% MVC (H50); exhausting rhythmic plantar flexion at 50% MVC (P50); H50 was added to P10 (P1OH50); and P50 was added to H10 (H10P50). Exercise duration, after handgrip was combined with plantar flexion (P10H50), was shorter than that of H50, although the exercise duration of HIOP50 was not significantly different from P50. No significant difference was found between the difference from rest in oxygen uptake (Δ $$\dot V$$ O2) during H10P50 and the sum of Δ $$\dot V$$ O2 during H10 and P50. Also, the differences from rest in forearm blood flow (Δ FBF) and calf blood flow (Δ CBF) during H10P50 were not significantly different from Δ FBF in H10 and from Δ CBF in P50. In contrast, Δ $$\dot V$$ O2 in P10H50 was lower than the sum of Δ $$\dot V$$ O2 in P10 and H50 (P 〈 0.05), and J FBF in P10H50 was lower than that in H50 (P 〈 0.05) , while Δ CBF was not significantly different between P1OH50 and P10. The changes in heart rate from rest (d HR) during the combined exercises were lower than the sums of Δ HR in the corresponding single exercises (P 〈 0.05). These results demonstrated an inhibitory summation of several cardiorespiratory responses to combined exercise resulting in a reduction in exercise performance which would seem to occur easily when upperlimb exercise is added to lower limb exercise.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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