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Digitale Medien

Transgenic and knockout mice in the study of neurodegenerative diseases (1996)

Aguzzi, A. ; Brandner, S. ; Marino, S. ; [weitere]

Springer

Journal of molecular medicine 74 (1996), S. 111-126

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ISSN: 1432-1440

Schlagwort(e): Key words Neurodegeneration ; Transgenic mouse ; Prions ; Spumavirinae ; Alzheimer’s disease ; Amyotrophic lateral sclerosis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer’s disease, and motor neuron diseases.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01575443

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