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Digitale Medien

Platelet heterogeneity based on lactic dehydrogenase activity (1992)

Sole, P. ; Zappacosta, B.

Springer

Annals of hematology 65 (1992), S. 135-137

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ISSN: 1432-0584

Schlagwort(e): Platelet ; Lactic dehydrogenase

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Mean lactic dehydrogenase (LDH) activity of human platelets is about 5 nU/platelet; expressed on a cell volume basis, it is 0.5 nU/fl. Platelet separation by means of centrifugation on a Percoll discontinuous gradient gives different subpopulations with a clear-cut change of LDH at a mean platelet volume (MPV) of about 6 fl. The LDH content of platelets with a MPV 〉6 fl is constant (about 0.5 nU/fl), while that of small platelets (3〈MPV〈6 fl) is inversely correlated with the MPV and reaches a value of 1.5–2.0 nU/fl. Because small platelets are granule-depleted, we suggest that platelet LDH activity be considered as an in vivo activation index.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01695813

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