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Digitale Medien

Modulation of EGF binding and action by succinylated concanavalin A in fibroblast cell cultures (1980)

Ballmer, Kurt ; Burger, Max M.

New York, N.Y. : Wiley-Blackwell

Journal of Supramolecular Structure 14 (1980), S. 209-214

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Details

ISSN: 0091-7419

Schlagwort(e): growth regulation ; epidermal growth factor ; density inhibition of growth ; extracellular matrix ; Life Sciences ; Molecular Cell Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Chemie und Pharmazie , Medizin

Notizen: The role of the binding of succinylated concanavalin A to tissue culture cells in influencing epidermal growth factor (EGF)-mediated cell proliferation has been studied. Succinylated concanavalin A dramatically reduces the stimulation of 3T6 cells by EGF in Dulbecco's modified Eagle's medium (DME) containing insulin and vitamin B12 as additional growth factors, but no serum. Furthermore, binding studies using 125I-labeled EGF have shown that the binding of EGF to the cell surface is reduced upon addition of succinylated concanavalin A.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jss.400140209

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